Grasas y Aceites, Vol 62, No 4 (2011)

Apricot and pumpkin oils reduce plasma cholesterol and triacylglycerol concentrations in rats fed a high-fat diet

Mohamed F. Ramadan
Agricultural Biochemistry Department, Faculty of Agriculture, Zagazig University - Chair of Engineer Abdullah Ahmad Baqshan for Bee Research, College of Food and Agricultural Sciences, King Saud University, Egypt

R. Zayed
Pharmacognosy Department, Faculty of Pharmacy, Zagazig University, Egypt

M. Abozid
Biochemistry Department, Faculty of Agriculture, Menofia University, Egypt

M. M. S. Asker
Microbial Biotechnology Department, National Research Center, Egypt


Non-conventional oilseeds are being taken into greater consideration because their constituents have unique chemical properties and may increase the supply of edible oils. The purpose of the present study was to investigate the effect of apricot kernel oil (AO) and pumpkin kernel oil (PO) on the lipid profiles and liver functions of rats fed high fat diets. The high fat diet resulted in great alterations in plasma lipid profiles and liver functions. Twenty-four male albino rats were used over a 28 day period. The animals were divided into 4 groups, where group 1 represents the negative control which were a fed basal diet, while group 2 received a high fat diet to serve as the hypercholesterolemic group (positive control). The other two groups were given a high fat diet supplemented with AO and PO. Group 3 was treated daily with AO (1g/Kg body weight), while group 4 was treated with PO (1g/Kg body weight). The plasma lipid profile and liver functions in the different groups were determined after 14 and 28 days. The rats in the treated groups (AO and PO) showed significantly lower levels of total cholesterol (TC), total triglycerides (TG), low density lipoprotein-cholesterol (LDL-C), alanine-aminotransferase (ALT) and aspartateaminotransferase (AST) activities as well as high levels of high density lipoprotein-cholesterol (HDL-C) and total protein in comparison with the hypercholesterolemic group. It could be concluded that AO and PO under study are useful for the treatment of hypercholesterolemia.


Apricot seed oil; Cholesterol; Fatty acids; HDL-cholesterol; Hypercholesterolemia; LDL-cholesterol; Polyunsaturated; Pumpkin seed oil

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