Grasas y Aceites, Vol 69, No 1 (2018)

Potential of Annona muricata L. seed oil: phytochemical and nutritional characterization associated with non-toxicity


https://doi.org/10.3989/gya.0777171

L. C. Pinto
Department of Food Science, School of Nutrition, Federal University of Bahia, Brazil
orcid http://orcid.org/0000-0001-7470-7074

C. O. de Souza
Faculty of Pharmacy, Federal University of Bahia, Brazil
orcid http://orcid.org/0000-0002-8028-5418

S. A. de Souza
Laboratory of Phytochemistry Bioprospecting, Federal Rural University of Pernambuco, Brazil
orcid http://orcid.org/0000-0001-9689-7614

H. B. da Silva
Institute of Health Sciences, Federal University of Bahia, Brazil
orcid http://orcid.org/0000-0003-1585-9099

R. R. da Silva
Department of Life Sciences, State University of Bahia, Brazil
orcid http://orcid.org/0000-0002-3422-0453

A. T. Cerqueira-Lima
Institute of Health Sciences, Federal University of Bahia, Brazil
orcid http://orcid.org/0000-0001-7991-4005

T. O. Teixeira
Institute of Health Sciences, Federal University of Bahia, Brazil
orcid http://orcid.org/0000-0001-7998-2569

T. M.S. da Silva
Laboratory of Phytochemistry Bioprospecting, Federal Rural University of Pernambuco, Brazil
orcid http://orcid.org/0000-0003-1887-2598

K. C.P. Medeiros
Federal University of Rio Grande do Norte, Brazil
orcid http://orcid.org/0000-0002-7784-0740

M. Bittencourt
Veterinary Hospital UNIME (HOSVET). Metropolitan Union of Education and Culture (UNIME), Brazil
orcid http://orcid.org/0000-0002-9893-173X

H. R. Brandão
Veterinary Hospital UNIME (HOSVET). Metropolitan Union of Education and Culture (UNIME), Brazil
orcid http://orcid.org/0000-0001-9061-7749

J. I. Druzian
Faculty of Pharmacy, Federal University of Bahia, Brazil
orcid http://orcid.org/0000-0001-8940-6098

A. S. Conceição
University of Bahia State, Department of Education, Herbarium of the State University of Bahia (HUNEB), Brazil
orcid http://orcid.org/0000-0002-8800-422X

M. V. Lopes
Department of Life Sciences, State University of Bahia, Brazil
orcid http://orcid.org/0000-0001-5985-8755

C. A. Figueiredo
Institute of Health Sciences, Federal University of Bahia, Brazil
orcid http://orcid.org/0000-0003-1356-6188

Abstract


The aim of this study was to evaluate the nutritional quality, phenolic compounds, fatty acid and antioxidant activity in vitro as well as a toxicological screening of A. muricata seed oil in vivo. The chemical composition and quantification of phenolic compounds were determined by the Adolfo Lutz Institute normative. The antioxidant activity was evaluated by DPPH, FRAP and ABTS methods. The oil was extracted by chloroform/ methanol and precipitated crude (AmPtO) and supernatant oils (AmSO) were obtained. The fatty acid profile was evaluated by gas chromatography and total compounds by HPLC-DAD. BALB/C mice received AmPtO and AmSO (0.5 and 1.0mL·Kg-1) for 14 days. Toxicity parameters were assessed. The major fatty acids in the oil were oleic (39.2%) and linoleic (33%). HPLC-DAD suggested the presence of acetogenins (annonacin: 595 [M-H]-), with a greater presence in AmPtO. The AmPtO group showed toxicity, which may be related to the acetogenin content in AmPtO. The AmSO group showed no toxicity and this oil has potential for food or medicinal use.

Keywords


Acetogenins; Annona muricata seeds; Annonacin; Linoleic acid; Oleic acid

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