Grasas y Aceites, Vol 55, No 4 (2004)

New heterocycles having double characters; as antimicrobial and surface active agents.


https://doi.org/10.3989/gya.2004.v55.i4.203

M. S. Amine
Chemistry Department, Faculty of Science, Benha Unviversity, Benha, Egypt

A. M. F.Eissa
Chemistry Department, Faculty of Science, Benha Unviversity, Benha, Egypt

A. A. El-Sawy
Chemistry Department, Faculty of Science, Benha Unviversity, Benha, Egypt

A. F. Shaaban
Chemistry Department, Faculty of Science, Benha Unviversity, Benha, Egypt

R. El-Sayed
Chemistry Department, Faculty of Science, Benha Unviversity, Benha, Egypt

Abstract


Fatty acids isothiocyanate (1) was used as a starting material to synthesize some important heterocycles such as triazoles, oxazoles, thiazoles, benzoxazoles and quinazolines by treating with different types of nucleophiles such as nitrogen nucleophiles, oxygen nucleophiles, and sulfur nucleophiles. The produced compounds were subjected to propylene oxide in different moles (n = 3, 5 and 7) to produce novel groups of nonionic compounds having the double function as antimicrobial and surface active agents which can be used in the manufacturing of drugs, cosmetics, pesticides or can be used as antibacterial and/or antifungal. The physical properties as surface and interfacial tension, cloud point, foaming height, wetting time, emulsification power and the critical micelle concentration (CMC) were determined, antimicrobial and biodegradability were also determined.

Keywords


Antimicrobial; Fatty acid isothiocyanate; Heterocycles; Surface active agents

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