Grasas y Aceites, Vol 60, No 1 (2009)

Diet-gene interactions between dietary fat intake and common polymorphisms in determining lipid metabolism


https://doi.org/10.3989/gya.086408

Dolores Corella
Department of Preventive Medicine and Public Health, University of Valencia and CIBER Fisiopatología de la Obesidad y Nutrición (CB06/03), ISCIII, Spain

Abstract


Current dietary guidelines for fat intake have not taken into consideration the possible genetic differences underlying the individual variability in responsiveness to dietary components. Genetic variability has been identified in humans for all the known lipid metabolim-related genes resulting in a plethora of candidate genes and genetic variants to examine in diet-gene interaction studies focused on fat consumption. Some examples of fat-gene interaction are reviewed. These include: the interaction between total intake and the 514C/T in the hepatic lipase gene promoter in determining high-density lipoprotein cholesterol (HDL-C) metabolism; the interaction between polyunsaturated fatty acids (PUFA) and the 75G/A polymorphism in the APOA1 gene plasma HDL-C concentrations; the interaction between PUFA and the L162V polymorphism in the PPARA gene in determining triglycerides and APOC3 concentrations; and the interaction between PUFA intake and the 1131TC in the APOA5 gene in determining triglyceride metabolism. Although hundreds of diet-gene interaction studies in lipid metabolism have been published, the level of evidence to make specific nutritional recommendations to the population is still low and more research in nutrigenetics has to be undertaken.

Keywords


Diet; Genes; Interaction; Lipids; Nutrigenetics; Polymorphisms

Full Text:


PDF

References


Bays HE, Tighe AP, Sadovsky R, Davidson MH. 2008. Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications. Expert. Rev. Cardiovasc.Ther. 6, 391-409. doi:10.1586/14779072.6.3.391 PMid:18327998

Brunner EJ, Rees K, Ward K, Burke M, Thorogood M. 2007.Dietary advice for reducing cardiovascular risk. Cochrane Database Syst Rev.: CD002128.

Chan E, Tan CS, Deurenberg-Yap M, Chia KS, Chew SK, Tai ES.2006.The V227A polymorphism at the PPARA locus is associated with serum lipid concentrations and modulates the lipoprotein concentrations in Chinese women. Atherosclerosis 187, 309-15. doi:10.1016/j.atherosclerosis.2005.10.002 PMid:16288935

Chiuve SE, Willett WC. 2007. The 2005 Food Guide Pyramid: an opportunity lost? Nat. Clin. Pract. Cardiovasc. Med. 4, 610-20. doi:10.1038/ncpcardio1009 PMid:17957208

Damjanovi M, Barton M. 2008. Fat intake and cardiovascular response. Curr. Hypertens. Rep. 10, 25-31. doi:10.1007/s11906-008-0007-0 PMid:18367023

Getz GS, Reardon CA. 2007. Nutrition and cardiovascular disease. Arterioscler. Thromb. Vasc. Biol. 27, 24992506. doi:10.1161/ATVBAHA.107.155853

Guri AJ, Hontecillas R, Bassaganya-Riera J. 2006. Peroxisome proliferator-activated receptors: bridging metabolic syndrome with molecular nutrition. Clin. Nutr. 25, 871-885. doi:10.1016/j.clnu.2006.08.006 PMid:17052808

Harris WS, Miller M, Tighe AP, Davidson MH, Schaefer EJ. 2008. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 197, 12-24. doi:10.1016/j.atherosclerosis.2007.11.008 PMid:18160071

Jump DB. 2002. Dietary polyunsaturated fatty acids and regulation of gene transcription. Curr. Opin. Lipidol. 13, 155-164. doi:10.1097/00041433-200204000-00007 PMid:11891418

Katan MB. 2005. The response of lipoproteins to dietary fat and cholesterol in lean and obese persons. Curr. Atheroscler Rep. 7, 460-465. doi:10.1007/s11883-005-0063-8 PMid:16256004

Kluger M, Heeren J, Merkel M. 2008. Apoprotein A-V: An important regulator of triglyceride metabolism. J. Inherit. Metab Dis. (in press). doi:10.1007/s10545-008-0863-4

Kris-Etherton PM, Harris WS, Appel LJ. 2002. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 106, 2747–2757. doi:10.1161/01.CIR.0000038493.65177.94 PMid:12438303

Lai CQ, Corella D, Demissie S, Cupples LA, Adiconis X, Zhu Y, Parnell LD, Tucker KL, Ordovas JM. 2006 Dietary intake of n-6 fatty acids modulates effect of apolipoprotein A5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: the Framingham Heart Study. Circulation 113, 2062-2070. doi:10.1161/CIRCULATIONAHA.105.577296 PMid:16636175

Le NA, Walter MF. 2007. The role of hypertriglyceridemia in atherosclerosis. Curr Atheroscler Rep. 9, 110-115. doi:10.1007/s11883-007-0006-7 PMid:17877919

Luan J, Browne PO, Harding AH, Halsall DJ, O’Rahilly S, Chatterjee VK, Wareham. 2001. Evidence for genenutrient interaction at the PPARgamma locus. Diabetes 50, 686-689. doi:10.2337/diabetes.50.3.686 PMid:11246892

Masson LF, McNeill G, Avenell A. 2003. Genetic variation and the lipid response to dietary intervention: a systematic review. Am. J. of Clin. Nutr. 77, 1098-1111.

Nettleton JA, Steffen LM, Ballantyne CM, Boerwinkle E, Folsom AR. 2007. Associations between HDLcholesterol and polymorphisms in hepatic lipase and lipoprotein lipase genes are modified by dietary fat intake in African American and White adults. Atherosclerosis 194, e131-140. doi:10.1016/j.atherosclerosis.2006.11.025 PMid:17157861 PMCid:2248232

Olivieri O, Martinelli N, Sandri M, Bassi A, Guarini P, Trabetti E, Pizzolo F, Girelli D, Friso S, Pignatti PF, Corrocher R. 2005. Apolipoprotein C-III, n-3 polyunsaturated fatty acids, and “insulin-resistant” T455C APOC3 gene polymorphism in heart disease patients: example of gene-diet interaction. Clin. Chem. 51, 360-367. doi:10.1373/clinchem.2004.040477 PMid:15576429

Ooi EM, Barrett PH, Chan DC, Watts GF. 2008. Apolipoprotein C-III: understanding an emerging cardiovascular risk factor. Clin. Sci. (Lond) 114, 611-624. doi:10.1042/CS20070308 PMid:18399797

Ordovas JM, Corella D, Cupples LA, Demissie S, Kelleher A, Coltell O, Wilson PW, Schaefer EJ, Tucker K. 2002. Polyunsaturated fatty acids modulate the effects of the APOA1 G-A polymorphism on HDL-cholesterol concentrations in a sex-specific manner: the Framingham Study. Am. J. Clin. Nutr. 75, 38-46.

Ordovas JM, Corella D. 2004. Nutritional genomics. Annu. Rev. Genomics. Hum. Genet 5, 71-118. doi:10.1146/annurev.genom.5.061903.180008 PMid:15485344

Pennacchio LA, Rubin EM. 2003. Apolipoprotein A5, a newly identified gene that affects plasma triglyceride levels in humans and mice. Arterioscler. Thromb. Vasc. Biol. 23, 529-534. doi:10.1161/01.ATV.0000054194.78240.45

Rioux V, Legrand P. 2007. Saturated fatty acids: simple molecular structures with complex cellular functions. Curr. Opin. Clin. Nutr. Metab. Care 10, 752-758.

Robitaille J, Després JP, Pérusse L, Vohl MC. 2003. The PPAR-gamma P12A polymorphism modulates the relationship between dietary fat intake and components of the metabolic syndrome: results from the Québec Family Study. Clin. Genet. 63, 109-116. doi:10.1034/j.1399-0004.2003.00026.x PMid:12630956

Rodriguez-Revenga L, Mila M, Rosenberg C, Lamb A, Lee C. 2007. Structural variation in the human genome: the impact of copy number variants on clinical diagnosis. Genet. Med. 9, 600-606. doi:10.1097/GIM.0b013e318149e1e3 PMid:17873648

Schaefer EJ, Lamon-Fava S, Ausman LM, Ordovas JM, Clevidence BA, Judd JT, Goldin BR, Woods M, Gorbach S, Lichtenstein AH. 1997. Individual variability in lipoprotein cholesterol response to National Cholesterol Education Program Step 2 diets. Am. J. Clin. Nutr. 65, 823-830.

Steinberg D. 2005. Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy: part II: the early evidence linking hypercholesterolemia to coronary disease in humans. J. Lipid. Res. 46, 179-190. doi:10.1194/jlr.R400012-JLR200

Tai ES, Corella D, Demissie S, Cupples LA, Coltell O, Schaefer EJ, Tucker KL, Ordovas JM. 2005. Framingham heart study. Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III concentrations in the Framingham Heart Study. J. Nutr. 135, 397-403.

Tai ES, Corella D, Deurenberg-Yap M, Adiconis X, Chew SK, Tan CE, Ordovas JM. 2004. Differential effects of the C1431T and Pro12Ala PPARgamma gene variants on plasma lipids and diabetes risk in an Asian population. J. Lipid. Res. 45, 674-685. doi:10.1194/jlr.M300363-JLR200

Tai ES, Corella D, Deurenberg-Yap M, Cutter J, Chew SK, Tan CE, Ordovas JM. 2003. Singapore National Health Survey. Dietary fat interacts with the –514C>T polymorphism in the hepatic lipase gene promoter on plasma lipid profiles in a multiethnic Asian population: the 1998 Singapore National Health Survey. J. Nutr. 133, 3399-3408.

Zhang C, Lopez-Ridaura R, Rimm EB, Rifai N, Hunter DJ, Hu FB. 2005. Interactions between the –514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men. Am. J. Clin. Nutr. 8, 1429-1435.




Copyright (c) 2009 Consejo Superior de Investigaciones Científicas (CSIC)

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


Contact us grasasyaceites@ig.csic.es

Technical support soporte.tecnico.revistas@csic.es