Grasas y Aceites, Vol 48, No 2 (1997)

Pharmacological activity of the fraction isolated from virgin olive oil containing the sterols and triterpenic alcohols

R. de la Puerta
Dpto. Farmacia, Tecnología Farmacéutica y Farmacología, Facultad de Farmacia, Sevilla, Spain

R. Maestro Durán
Instituto de la Grasa (C.S.I.C.)., Spain

V. Ruiz Gutiérrez
Instituto de la Grasa (C.S.I.C.)., Spain


The fraction of sterols and triterpenic dialcohols from unsaponifiable of virgin olive oil has been tested for Its possible antiinflamatory activity. The topical administration of these products produced a potent antioedematous effect, in the auricular oedema induced by TPA (12-0-tetradecanoylphorbol acetate) in experimental animals. This test has been widely used to determine the antiinflamatory action of phospholipase A2 inhibitors. The measure of myeloperoxidase, marker enzyme of the accumulation of neutrophils in the inflamed tissue, demonstrated a significant reduction of the cellular infiltration produced by assayed fraction.


Antiinflamatory activity; Sterol; Triterpene alcohol; Virgin olive oil.

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Copyright (c) 1997 Consejo Superior de Investigaciones Científicas (CSIC)

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