Grasas y Aceites, Vol 46, No 1 (1995)

Phosphatidic acid production regulated by receptors with liganddependent tyrosine kinase activity

Fco. J. G. Muriana
Instituto de la Grasa (CSIC)s, Spain

V. Ruiz-Gutiérrez
Instituto de la Grasa (CSIC), Sevilla, Spain


The present study deals with the most recent and important studies on the relationship between transmembrane receptors with ligand-dependent tyrosine kinase activity and cellular lipid metabolism, predominantly in generating phosphatidic acid (PA) as a lipid messenger. The signaling function of phosphatidylcholine hydrolysis and diacylglycerol (DG) phosphorylation by phospholipase D and diacylglycerol kinase, respectively, as different sources for PA is also described. PA may play a role in signal transduction as a putative first or second messenger, and acts to reduce levels of DG and to produce bis-PA by phospholipase D - mediated transphosphatidylation.


Diacylglycerol kinase; Information (paper); Ptiospfiatidic acid; Phospholipase D; Recepto; Tyrosine kinase activity

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Copyright (c) 1995 Consejo Superior de Investigaciones Científicas (CSIC)

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