Lipophilic components and evaluation of the cytotoxic and antioxidant activities of <em>Impatiens glandulifera</em> Royle and <em>Impatiens noli – tangere</em> L. (Balsaminaceae)

K. Szewczyk; R. Bonikowski; A. Maciąg-Krajewska; J. Abramek; A. Bogucka-Kocka

doi:10.3989/gya.0234181

Authors

K. Szewczyk Department of Pharmaceutical Botany, Medical University of Lublin https://orcid.org/0000-0003-4884-9110
R. Bonikowski Łódź University of Technology, Faculty of Biotechnology and Food Sciences, Institute of General Food Chemistry https://orcid.org/0000-0003-3327-8984
A. Maciąg-Krajewska Łódź University of Technology, Faculty of Biotechnology and Food Sciences, Institute of General Food Chemistry https://orcid.org/0000-0001-9892-1219
J. Abramek Department of Biology and Genetics, Medical University of Lublin https://orcid.org/0000-0001-7925-4350
A. Bogucka-Kocka Department of Biology and Genetics, Medical University of Lublin https://orcid.org/0000-0001-8473-7429

DOI:

https://doi.org/10.3989/gya.0234181

Keywords:

Antioxidant, Cytotoxicity, Fatty acids, Impatiens, Phytosterols, Triterpenoids

Abstract

The chemical composition of the lipophilic fractions of Impatiens glandulifera Royle and I. noli-tangere L. were analyzed by gas chromatography-mass spectrometry (GC-MS)., The study focused on the fatty acids, triterpenoids and sterols in the leaves, roots and seeds. Most of the identified compounds are new for these species. a-linolenic, oleic and palmitic acids were the most abundant in the fatty acid fractions, β-amyrin and 5a-lup-20(29)-en-3β-ol in the triterpenoid fractions, and β-sitosterol, spinasterol and chondrillasterol in the sterol fractions. The fatty acid and triterpenoid fractions showed strong antioxidant activity, similar to positive controls. Moreover, the triterpenoid fraction from I. noli-tangere seeds significantly inhibited HL-60 human leukemia cells. Other fractions showed moderate cytotoxicity. The present study suggests that I. glandulifera and I. noli-tangere are good source of omega-3 fatty acids, and they might be considered as antioxidant and chemopreventive agents.

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