TY - JOUR AU - Pinto, L. C. AU - de Souza, C. O. AU - de Souza, S. A. AU - da Silva, H. B. AU - da Silva, R. R. AU - Cerqueira-Lima, A. T. AU - Teixeira, T. O. AU - da Silva, T. M.S. AU - Medeiros, K. C.P. AU - Bittencourt, M. AU - Brandão, H. R. AU - Druzian, J. I. AU - Conceição, A. S. AU - Lopes, M. V. AU - Figueiredo, C. A. PY - 2018/03/30 Y2 - 2024/03/28 TI - Potential of Annona muricata L. seed oil: phytochemical and nutritional characterization associated with non-toxicity JF - Grasas y Aceites JA - Grasas aceites VL - 69 IS - 1 SE - Research DO - 10.3989/gya.0777171 UR - https://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/1701 SP - e234 AB - The aim of this study was to evaluate the nutritional quality, phenolic compounds, fatty acid and antioxidant activity in vitro as well as a toxicological screening of <em>A. muricata</em> seed oil <em>in vivo</em>. The chemical composition and quantification of phenolic compounds were determined by the Adolfo Lutz Institute normative. The antioxidant activity was evaluated by DPPH, FRAP and ABTS methods. The oil was extracted by chloroform/ methanol and precipitated crude (<em>AmPtO</em>) and supernatant oils (<em>AmSO</em>) were obtained. The fatty acid profile was evaluated by gas chromatography and total compounds by HPLC-DAD. BALB/C mice received <em>AmPtO</em> and <em>AmSO</em> (0.5 and 1.0mL·Kg<sup>-1</sup>) for 14 days. Toxicity parameters were assessed. The major fatty acids in the oil were oleic (39.2%) and linoleic (33%). HPLC-DAD suggested the presence of acetogenins (annonacin: 595 [M-H]-), with a greater presence in <em>AmPtO</em>. The <em>AmPtO</em> group showed toxicity, which may be related to the acetogenin content in <em>AmPtO</em>. The <em>AmSO</em> group showed no toxicity and this oil has potential for food or medicinal use. ER -