TY - JOUR AU - de Pablo Martínez, M. A. AU - Ortega Morente, E. AU - Gallego Cabrera, A. Mª AU - Alvarez Nieto, C. AU - Alvarez de Cienfuegos López, G. PY - 2000/06/30 Y2 - 2024/03/28 TI - Immunomodulation carried out by dietary fatty acids in experimental animals and humans JF - Grasas y Aceites JA - Grasas aceites VL - 51 IS - 3 SE - Reviews DO - 10.3989/gya.2000.v51.i3.478 UR - https://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/478 SP - 190-195 AB - Several studies have reported that fatty acids act as modulatory agents of immune response of experimental animals and humans. In this paper, we do and overview of the performed studies by using of unsaturated fatty acids and their influence on several immunitary parameters in studies carried out <i>in vitro</i> as well as <i>ex vivo</i>. It has been shown that unsaturated fatty acids are involved in the reduction of lymphocyte proliferation, cytokine production and natural killer cell activity. On the other hand, in this article we have reviewed the mechanisms by which fatty acids modulate the immune response: I) membrane fluidity alteration; II) production of lipid peroxides; III) eicosanoid production; IV) gene expression modulation. ER -