Grasas y Aceites, Vol 67, No 4 (2016)

Effect of extra virgin olive oil components on the arachidonic acid cascade, colorectal cancer and colon cancer cell proliferation


https://doi.org/10.3989/gya.0450161

C. E. Storniolo
Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, Institute of Nutrition and Food Safety (INSA-UB), University of Barcelona, Spain

J. J. Moreno
Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, Institute of Nutrition and Food Safety (INSA-UB), University of Barcelona, Spain

Abstract


The mediterranean diet (MD) reduced the risk of colorectal cancer (CRC), and olive oil, the primary source of fat in the MD, has also been found to have a protective effect. However, animals fed with oleic acid present a high number of intestinal tumours, suggesting that oleic acid and olive oil consumption can exert different effects on CRC. Considering that extra virgin olive oil (EVOO) is a complex mix of fatty acids and minor compounds such as polyphenols, hydrocarbons, phytosterols and triterpenes; and that these compounds have antioxidant activity and consequently they can modulate the arachidonic acid (AA) cascade and eicosanoid synthesis. This review analyzes the state of the art of olive oil components on the AA cascade and cellular mechanism involved in CRC such as intestinal epithelial cell growth/apoptosis, to understand the fact that the consumption of seed oils with high oleic content or EVOO will probably have different effects on CRC development.

Keywords


Cell growth; Colorectal cancer; Eicosanoid; Oleic acid; Oxidative stress; Polyphenol

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References


Barone M, Notarnicola M, Caruso MG, Scavo MP, Viggiani MT, Tutino V, Polimeno L, Pesetti B, Di Leo A, Francavilla A. 2014. Olive oil and omega-3 polyunsaturated fatty acids suppress intestinal polyp growth by modulating the apoptotic process in ApcMin/+ mice. Carcinogenesis 35, 1613–1619. https://doi.org/10.1093/carcin/bgu068 PMid:24632492

Bartoli R, Fernández-Banares F, Navarro E, Castella E, Mane J, Alvarez M, Pastor C, Cabre E, Gassull MA. 2000. Effect of olive oil on earlyandlateevents of colon carcinogènesis in rats: modulation of arachidonicacidmetabolismand local prostaglandin E2 synthesis. Gut 46, 191–199. https://doi.org/10.1136/gut.46.2.191 PMid:10644312 PMCid:PMC1727832

Bartsch H, Nair J, Owen RW. 1999. Dietary polyunsaturated fatty acids and cancers of the breast and colorectum emerging evidence dor their role as risk modifiers. Carcinogenesis 20, 2209–2218. https://doi.org/10.1093/carcin/20.12.2209 PMid:10590211

Braga C, La Vecchia C, Franceshi S, Negri E, Parpinel M, Decarli A, Giacosa A, Trichopoulos D. 1998. Olive oil, other seasoning fats and the risk of colorectal carcinoma. Cancer 82, 448–453. https://doi.org/10.1002/(SICI)1097-0142(19980201)82:3<448::AID-CNCR4>3.0.CO;2-L

Cabral M, Martin-Venegas R, Moreno JJ. 2013. Role of arachidonic acid metabolites on the control of non-differentiated intestinal epithelial cell growth. Int. J. Biochem. Cell Biol. 45, 1620–1628. https://doi.org/10.1016/j.biocel.2013.05.009 PMid:23685077

Cabral M, Martin-Venegas R, Moreno JJ. 2014. Differential cell growth/apoptosis behaviour of 13-hydroxyoctadecadienoic acid enantiomers in a colorectal cancer cell line. Am. J. Physiol. Gastrointest. Liver Physiol. 307, G664-G671. https://doi.org/10.1152/ajpgi.00064.2014 PMid:25035111

Cabral M, Martin-Venegas R, Moreno JJ. 2015. Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis. Physiol. Rep. 3, e12417. https://doi.org/10.14814/phy2.12417 PMid:26216432 PMCid:PMC4552517

Cianchi F, Cortesini C, Magnelli L, Fanti E, Papucci L, Schiavone N, Messerini L, Vannacci A, Capaccioli S, Perna F, Lulli M, Fabbroni V, Perigli G, Bechi P, Masini E. 2006. Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells. Mol. Cancer Ther. 5, 2716–2726. https://doi.org/10.1158/1535-7163.MCT-06-0318 PMid:17121918

Couto E, Boffeta P, Lagiou P, Ferrari P, Buckland G, Overvad K, Dahm CC, Tjønneland A, Olsen A, Clavel-Chapelon F, Boutron-Ruault MC, Cottet V, Trichopoulos D, Naska A, Benetou V, Kaaks R, Rohrmann S, Boeing H, von Ruesten A, Panico S, Pala V, Vineis P, Palli D, Tumino R, May A, Peeters PH, Bueno-de-Mesquita HB, Büchner FL, Lund E, Skeie G, Engeset D, Gonzalez CA, Navarro C, Rodríguez L, Sánchez MJ, Amiano P, Barricarte A, Hallmans G, Johansson I, Manjer J, Wirfärt E, Allen NE, Crowe F, Khaw KT, Wareham N, Moskal A, Slimani N, Jenab M, Romaguera D, Mouw T, Norat T, Riboli E, Trichopoulou A.2011. Mediterranean dietary pattern and cancer risk in the EPIC cohort. Br. J. Cancer 104, 1493–1499. https://doi.org/10.1038/bjc.2011.106 PMid:21468044 PMCid:PMC3101925

De la Puerta R, Ruiz-Gutiérrez V, Hoult JR. 1999. Inhibition of leukocyte 5-lipoxygenase by phenolics from virgin olive oil. Biochem. Pharmacol. 67, 445–449. https://doi.org/10.1016/S0006-2952(98)00320-7

Ferrer R, Moreno JJ. 2010. Role of eicosanoids on intestinal epithelial homeostasis. Biochem. Pharmacol. 80, 431–438. https://doi.org/10.1016/j.bcp.2010.04.033 PMid:20457139

Franceshi S, La Vecchia C, Russo A, Favero A, Negri E, Conti E, Montella M, Filiberti R, Amadori D, Decarli A. 1998. Macronutrient intake and risk of colorectal cancer in Italy. Int. J. Cancer 76, 321–324. https://doi.org/10.1002/(SICI)1097-0215(19980504)76:3<321::AID-IJC6>3.0.CO;2-X

Hong KH, Bonventre JC, O' Leary E, Bonventre JV, Lander ES. 2001. Deletion of cytosolic phospholipase A2 suppresses ApcMin-induced tumorigenesis. Procc. Natl. Acad. Sci. USA 98, 3935–3939. https://doi.org/10.1073/pnas.051635898 PMid:11274413 PMCid:PMC31157

Ihara A, Wada K, Yoneda M, Fujisawa N, Takahashi H, Nakajima A. 2007. Blockade of leukotrienes B4 signaling pathway induced apoptosis and suppresses cell proliferation in colon cancer. J. Pharmacol. Sci. 103, 24–32. https://doi.org/10.1254/jphs.FP0060651 PMid:17220595

Koehne CH, Dubois RN. 2004. COX-2 inhibition and colorectal cancer. Semin. Oncol. 31, 12–21. https://doi.org/10.1053/j.seminoncol.2004.03.041 PMid:15252926

Magnusson C, Ehrnström R, Olsen J, Sjölander A. 2007. An increased expression of cysteinyl leukotriene 2 receptor in colorectal adenocarcinomas correlates with high differentiation. Cancer Res. 67, 9190–9198. https://doi.org/10.1158/0008-5472.CAN-07-0771 PMid:17909024

Martin-Venegas R, Jáuregui O, Moreno JJ. 2014. Liquid chromatography-tandem mass spectrometry analysis of eicosanoids and related compounds in cell models. J. Chromatogr. B 964, 47–49. https://doi.org/10.1016/j.jchromb.2014.05.024 PMid:24932539

Martínez J, Moreno JJ. 2001. Role of Ca2+-independent phospholipase A2 on arachidonic acid release induced by reactive oxygen species. Arch. Biochem. Biophys. 392, 257–262. https://doi.org/10.1006/abbi.2001.2439 PMid:11488600

Martínez-Hovelman N, Storniolo CE, Moreno JJ. 2013. Effects of olive oil minor components on intestinal epithelial cancer cell growth induced by oleic acid. Ann. Nutr. Metab. 62, 34.

Moran AE, Hunt DH, Javid SH, Redston M, Carothers AM, Bertagnolli MM. 2004. Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice. J. Biol. Chem. 279, 43261–43272. https://doi.org/10.1074/jbc.M404276200 PMid:15294912

Moreno JJ, Carbonell T, Sanchez T, Miret S, Mitjavila MT. 2001. Olive oil decreases both oxidative stress and the production of arachidonic acid metabolites by the prostaglandin G/H synthase pathway in rat macrophages. J. Nutr. 131, 2145–2149. PMid:11481409

Moreno JJ. 2003. Effect of olive oil minor components on oxidative stress and arachidonic acid mobilization and metabolism by macrophages RAW 264.7. Free Radic. Biol. Med. 35, 1073–1081. https://doi.org/10.1016/S0891-5849(03)00465-9

Mitjavila MT, Fandos M, Salas-Salvado J, Covas MI, Borrego S, Estruch R, Lamuela-Raventós R, Corella D, Martínez- Gonzalez MÁ, Sánchez JM, Bulló M, Fitó M, Tormos C, Cerdá C, Casillas R, Moreno JJ, Iradi A, Zaragoza C, Chaves J, Sáez GT. 2013. The Mediterranean diet improves the systemic lipid and DNA oxidative damage in metabolic syndrome individuals. A randomized, controlled, trial. Clin. Nutr. 32, 172–178. https://doi.org/10.1016/j.clnu.2012.08.002 PMid:22999065

Notarnicola M, Pisanti S, Tutino V, Bocale D, Rotelli MT, Gentile A, Memeo V, Bifulco M, Perri E, Caruso MG. 2001. Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells. Genes Nutr. 6, 63–69. https://doi.org/10.1007/s12263-010-0177-7 PMid:21437031 PMCid:PMC3040798

Oshima M, Dinchuk JE, Kargman SL, Oshima H, Hancock B, Kwong E, Trzaskos JM, Evans JF, Takedo MM. 1996. Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87, 803–809. https://doi.org/10.1016/S0092-8674(00)81988-1

Pelucchi C, Bosetti C, Negri E, Lipworth L, La Vecchia C. 2011. Olive oil and cancer risk: an update of epidemiological findings through 2010. Curr. Pharm. Des. 17, 805–812. https://doi.org/10.2174/138161211795428920 PMid:21443483

Petrik MB, McEntee MF, Chiu CH, Whelan J. 2000. Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc (Min/+) mice. J. Nutr. 130, 1153–1158. PMid:10801912

Reedy J, Miltrou PN, Krebs-Smith SM, Wirfalt E, Flood A, Kipnis V, Leitzmann M, Mouw T, Hollenbeck A, Schatzkin A. 2008. Index-based dietary patterns and risk of colorectal cancer: the NIH-AARP Diet and Health Study. Am. J. Epidemiol. 168, 38–48. https://doi.org/10.1093/aje/kwn097 PMid:18525082

Sánchez T, Moreno JJ. 2002. Calcium-independent phospholipase A2 through arachidonic acid mobilization is involved in Caco-2 cell growth. J. Cell Physiol. 193, 293–298. https://doi.org/10.1002/jcp.10162 PMid:12384982

Sofi F, Abbate R, Gensini GF. Casini A, Trichopoulou A, Bamia C. 2011. Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systemic review and meta-analysis. Am. J. Clin. Nutr. 92, 1189–1196. https://doi.org/10.3945/ajcn.2010.29673 PMid:20810976

Thun MJ, Namboodiri MM, Calle EE, Flanders WD, Jr. Heath CW. 1991. Aspirin use and reduced risk of fatal colon cancer. New Engl. J. Med. 325, 1593–1596. https://doi.org/10.1056/NEJM199112053252301 PMid:1669840

Visioli F, Bellomo G, Galli C. 1998. Free radical-scavenging properties of olive oil polyphenols. Biochem. Biophys. Res. Commun. 247, 60–64. https://doi.org/10.1006/bbrc.1998.8735 PMid:9636654

Vivancos M, Moreno JJ. 2008. Effect of resveratrol, tyrosol and beta-sitosterol on oxidized low-density lipoprotein-stimulared oxidative stress, arachidonic acid release and prostaglandin E2 synthesis by RAW 264.7 macrophages. Br. J. Nutr. 99, 1199–1207. https://doi.org/10.1017/S0007114507876203 PMid:18081942

Watanabe K, Kawamori T, Nakatsugi S, Ohta T, Ohuchida S, Yamamoto H, Maruyama T, Kondo K, Ushikubi F, Narumiya S, Sugimura T, Wakabayashi K. 1999. Role of the prostaglandin E receptor subtype EP1 in colon carcinogensis. Cancer Res. 59, 5093–5096. PMid:10537280




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