The importance of the fatty acids in breast milk and in lacteal formulae.
DOI:
https://doi.org/10.3989/gya.083411Keywords:
Fatty acids, Lacteal formulae, MexicoAbstract
The best choice for feeding the newborn child is breast milk, and when it is not possible to breastfeed a baby, the breast milk is replaced by lacteal formula, which is why numerous studies focus their attention on the analysis of the diverse components of baby formula as well as functions in the breastfed baby. Fatty acids are components of great nutritional importance in the fetus and in the newborn child. Nowadays it is estimated that the fetus, during the last trimester of the gestational period and the newborn child, during the first six months of life, need a great contribution of araquidonic and docosahexaenoic acids, due to the fact that the speed of transformation of the predecessors to the hepatic level are not sufficient to cover the metabolic requirements of these fatty acids and it is the mother who contributes them through placental transport during gestation and her milk during lactation. The Organization of Food and Agriculture (FAO), the World Health Organization (WHO), the European Society of Gastroenterology, Hepatology and Pediatric Nutrition (ESPGHAN) and the American Academy of Pediatrics recommend that lacteal formula imitate the composition of the breast milk, especially in the fatty polyunsaturated acids (PUFA).
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References
Adamkin D. 2007. Controversias en nutrición neonatal: ácido docosahexanoico (DHA) y nucleótidos. J. Perinatol. 27, S79-S82. http://dx.doi.org/10.1038/sj.jp.7211711
Agostoni C, Trojan S, Bellu R, Riva E, Giovannini M. 1995 Neurodevelopmental Quotient of Healthy Term Infants at 4 Months and Feeding Practice: The Role of Long-Chain Polyunsaturated Fatty Acids. Pediat. Res. 38, 262-266. http://dx.doi.org/10.1203/00006450-199508000-00021 PMid:7478826
Auestad N, Scott D, Janowsky J, Jacobsen C, Carroll R, Montalto M, Halter R, Qiu W, Jacobs J, Connor W, Connor S, Taylor J, Neuringer M, Fitzgerald K, Hall R. 2003. Visual Cognitive, and Language Assessments at 39 months. A Follow-up Study of Children Fed Formulas Containing Long-Chain Polyunsaturated Fatty Acids to 1 Year of age. Pediatrics.112, e177-e183. http://dx.doi.org/10.1542/peds.112.3.e177 PMid:12949309
Bosch V, Golfeno I, Alonso H, Laurentin Z, Materan M, García N. 2009. Ácidos grasos de la leche maternal de mujeres venezolanas de estratos socioeconómicos bajos: Influencia de la temperatura y tiempo de almacenamiento. Arch. Latinoam. Nutr. 59, 61-65. PMid:19480345
Bouwstra H, Dijck-brouwer D, Boehm G, Boersma E, Muskiet F, Hadders-Algra M. 2005. Long-chain polyunsaturated fatty acids and neurological developmental outcome at 18 months in healthy term infants. Acta Pediatr. 94, 26-32. http://dx.doi.org/10.1080/08035250410020190 PMid:15858956
Campoy C, Cabero L, Sanjurjo P, Serra-Majem L, Anadón A, Morán J, Fraga J. 2010. Actualización, recomendaciones y consenso sobre el papel de los ácidos grasos poliinsaturados de cadena larga en la gestación, lactancia y primer año de vida. Med. Clin. 135, 75-82. http://dx.doi.org/10.1016/j.medcli.2010.02.010 PMid:20434734
Carmona M. 2005. Lípidos en la nutrición del neonato prematuro. PAC Neonatología 2.Libro6, 416-424.
Carver J. 2003. Advances in nutritional modification of infant formulas. Am. J. Clin. Nutr. 77, 1550-1554.
Cheatham C, Colombo J, Carlson S. 2006. N-3 Fatty acids and cognitive and visual acuity development: methodologic and conceptual considerations. Am. J. Clin. Nutr. 83, 1458-1466.
Colombo J, Kannass K, Jill D, Kundurthi S, Maikranz J, Anderson C, Blaga O, Carlson S. 2004. Maternal DHA and the Development of Attention in Infancy and Toddlerhood. Child Development. 75, 1254-1267. http://dx.doi.org/10.1111/j.1467-8624.2004.00737.x PMid:15260876
Contreras A, Herrera Y, Rodríguez L, Pizzarro T, Atalah E. 2011. Acceptability and consumption of a dairy drink with omega-3 in pregnant and lactating women of the national supplementary food program. Rev. Chil. Nutr. 38, 313-320.
Coronado M, Vega y León S, Gutiérrez R, García B, Díaz G. 2006. Los Ácidos grasos Omega-3 y Omega-6: Nutrición, Bioquímica y Salud. REB. 25, 72-79.
Cunninghaim P, McDermott L. 2008. Long Chain PUFA Transport in Human Term Placenta. J. Nutrit. 139, 636-639. http://dx.doi.org/10.3945/jn.108.098608 PMid:19225129
Eritsland J. 2000.Safety considerations of polyunsaturated fatty acids. Am. J. Clin. Nutr. 71, 197S-201S. PMid:10617971
Fernández J. 2010. Ácidos grasos omega-3 y prevención cardiovascular. Rev. CENIC. 41, 3-15.
García E, Gutiérrez S, Nolasco H. 2007. Desarrollo de bebidas lácteas enriquecidas con ácidos grasos. Rev. Tecnol. Láctea Latinoam. 36 online. www.publitec.com
García R. 2011. Composición e inmunología de la leche humana. Acta Pediatr. Mex. 32, 223-230.
Georgieff M. 2007. Nutrition and the developing brain: nutrient priorities and measurement. Am. J. Clin. Nutr. 85, 614S-220S. PMid:17284765
Gil A, Uauy R, Dalmau J. 2006. Comité de Nutrición de la AEP. Bases para una alimentación complementaria adecuada de los lactantes y los niños de corta edad. An. Pediatr. 65, 481-495.
Gil-Campos M y Dalmau J. 2010. Importancia del ácido docosahexaenoico (DHA): funciones y recomendaciones para su ingesta en la infancia. An. Pediatr. 73, 142.e1.-142.e8.
Haschke-Becher E, Fazzolari-Noesci A, Minoli I, Räihä N, Carrié A-L, Haschke F, Bachman C. 2001.Perfiles de ácidos grasos en lactante alimentados con formulas suplementadas con ácidos grasos poliinsaturados de cadena larga. Nestle Nutrition Workshop Series. Pediatric Program. 47(S), 49-53.
Innis S. 2003. Perinatal biochemistry and physiology of long-chain polyunsaturated fatty acids. J. Pediatr. 143, S1-S8. http://dx.doi.org/10.1067/S0022-3476(03)00396-2
Innis S. 2007. Metabolismo lipídico del lactante prematuro. Pediatr. Rev. 24, 256-265.
Koletzko B, Agostoni C, Carlson SE, Clandinin T, Hornstra G, Neuringer M, Uuay R, Yamashiro Y, Willatts M. 2001. Long chain polyunsaturated fatty acids (LCPUFA) and perinatal development. Acta Pediatr. 90, 460-464. http://dx.doi.org/10.1111/j.1651-2227.2001.tb00452.x
Lama R, Moráis A. 2005. Las grasas en la alimentación infantil. Importancia de los ácidos grasos poliinsaturados. An. Pediatr. Monogr. 3,16-23.
Lindquist S, Hernell O. 2010. Lipid digestion and absorption in early life: an update. Curr. Opin. Clin. Nutr. 13, 314-320. http://dx.doi.org/10.1097/MCO.0b013e328337bbf0 PMid:20179589
Macías S, Rodríguez S, Ronayne de Ferrer P. 2006. Leche materna: composición y factores condicionantes de la lactancia. Arch. Argent. Pediatr. 104, 423-430.
Makrides M, Collins C, Gibson R. 2011. Impact of fatty acid status on growth and neurobehavioural development in humans. Matern. Child Nutri. 7, 80-88. http://dx.doi.org/10.1111/j.1740-8709.2011.00304.x
Marmor M, Holder G, Seeliger M, Yamamoto S. 2004. Standard for clinical electroretinography (2004 update). Doc. Opthalmol. 108, 107-114. http://dx.doi.org/10.1023/B:DOOP.0000036793.44912.45 PMid:15455793
Martínez V, Aranceta J, Dalmau J, Gil A, Lama R, Martín M, Moreno J, Pavón P, Suárez L. 2009. Recomendaciones nutricionales en la infancia. JANO. 1749, 42-47.
Martinez A y Ballew M. 2011. Infant formulas. Pediatr. Rev. 32, 179-189. http://dx.doi.org/10.1542/pir.32-5-179 PMid:21536776
Mc Namara R, Carlson S. 2006. Role of omega-3 fatty acids in brain development and function: Potential implications for the pathogenesis and prevention of psychopathology. Prostag. Leukotr. Ess. 75, 329-349. http://dx.doi.org/10.1016/j.plefa.2006.07.010 PMid:16949263
McGregor J, Carlson S, Hobel C, Mei S, Ogburn P. 2003. Nutritional roles of omega-3 fatty acids during pregnancy and neonatal development. OBG Management. DowdenHealth Media Inc. (Suppl), S1-S12.
Mena P, Milad A. 1998. Variaciones en la composición nutricional de la leche materna. Algunos aspectos de importancia clínica. Rev. Chil. Pediatr. 69, 116-121.
Mepham T. 1993.“Humanizing” milk: The formulation of artificial feeds for infants (1850-1910). Med. His. 37, 225-249.
Minihane A. 2009. Nutrient gene interactions in lipid metabolism. Curr. Opin. Clin. Nutrit. 12, 357-363. http://dx.doi.org/10.1097/MCO.0b013e32832c94a5 PMid:19455028
Morales E. 1994. Ácidos grasos poliinsaturados de cadena larga en la nutrición del lactante. Rev. Hosp. Mat. Inf. Ramón Sardá. 13, 73-75. PMid:11114686
Morris G, Moorcraft J, Mountjoy A, Wells JCK. 2000. A novel infant formula milk with added long-chain polyunsaturated fatty acids from single-cel sources: a study of growth, satisfaction and health. Eur. J. Clin. Nutrit. 54, 883-886. http://dx.doi.org/10.1038/sj.ejcn.1601111 PMid:21699757
Mourek J, Mourek J Jr. 2011. Developmentally dependent and different roles of fatty acids omega-6 and omega-3. Prague Medical Report. 112, 81-92. PMid:10617981
Neuringer M. 2000. Infant vision and retinal functi9on in studies of dietary long-chain polyunsaturated fatty acids: methods, results, and implications. Am. J. Clin. Nutr. 71, 256S-267S.
Novo L. 2010. Los lípidos en la nutrición infantil. Rev. Cubana Aliment. Nutr. 20, S1-S28.
Paulou A, Badiola J, Anadón A, Bosch A, Cacho J, Cameán A, Cepeda A, Domínguez L, Farré R, Juárez M, Martín F, Martín M, Mas A, Ortega T, Otero A, Paseiro P, Ramón D, Rodríguez E, Vidal M, Zurera G. 2010. Informe del Comité Científico de la Agencia Española de Seguridad Alimentaria y Nutrición (AESAN) sobre el riesgo asociado a la presencia de ácidos grasos trans en alimentos. Revista del Comité Científico. 12, 95-114. PMid:20630202
Prosser C, Svetashev V, Vyssotski M, Lowry D. 2010. Composition and distribution of fatty acids in triglycerides from goat infant formulas with milk fat. J. Dairy Sci. 93, 2857-2862. http://dx.doi.org/10.3168/jds.2009-2946 PMid:12792656
Rodriguez A, Raederstorff D, Sarda P, Lauret C, Mendy F, Descomps B. 2003. Preterm infant formula supplementation with α linolenic acid and docosahexaenoic acid. Eur. J. Clin. Nutrit. 57, 727-734. http://dx.doi.org/10.1038/sj.ejcn.1601604
Rodríguez Y, Pita G, Martín I, Ferret A, Puentes I. 2004. Las grasas en la dieta materna, edad gestacional y peso al nacer. Rev. Cubana Salud Pública. 30, 1-10.
Ros-Berruezo G. 2007. Importancia del componente graso en la dieta del niño de 6 a 12 meses de edad. Anal. Real Acad. Ciencias Veterinarias de Andalucía Oriental. 20, 69-90. PMid:18691337
Rosenfeld E, Beyerlein A, Hadders-Algra M, Kennedy K, Singhal A, Fewtrell M, Lucas A, Koletzko B, Von Kies R. 2009. IPD meta-analysis shows no effect of LCPUFA supplementation on infant growth at 18 months. Acta Pediatr. 98, 91-97. http://dx.doi.org/10.1111/j.1651-2227.2008.00988.x PMid:15051839
Sala-Vila A, Castellote A, Campoy C, Rivero M, Rodríguez- Palmero M, López-Sabater C. 2004. The source of Long-Chain PUFA in Formula Supplements Does Not Affect the Fatty Acid Composition of Plasma Lipids in Full-Term Infants. J. Nutr. 134, 868-873.
Sánchez C, Narciso D, Rivero M, Sánchez S, Johnston S, Sánchez J, Rodríguez A, Cubero J. 2008. Nociones en alimentación y nutrición infantil durante el primer año de vida. Enfermería Global. 12, 1-8.
Sanhueza J, Nieto S, Valenzuela A. 2004. Ácido docosahexaenoico (DHA), el desarrollo cerebral, memoria y aprendizaje: La importancia de la suplementación perinatal. Rev. Chil. Nutr. 31, 1-15.
Sanjurjo, Trebolazabala N, Aldámiz-Echevarría L, Castaño L, Prieto J, Lodeiro A. 2008. Ácidos grasos n-3 y n-6 en plasma al nacer y al año de edad y relación con el tipo de alimentación. An. Pediatr. 68, 570-575. PMid:2564887
Simopoulos A. 1989. Summary of the NATO Advance3d Research Workshop on Dietary ω· and ω 6 Fatty Acids: Biological Effects and Nutritional Essentiality. J. Nutr. 119, 521-528.
Surh J, Lee S, Kwpn H. 2007. 4-Hydroxy-2-alkenal in polyunsaturated fatty acids-fortified infant formulas and other commercial food products. Food Addit. Contam. 24, 1209-1218. http://dx.doi.org/10.1080/02652030701422465 PMid:19752537
Uauy R, Dangour A. 2009. Fat and fatty acid requirements and recommendations for infants of 0-2 years and children of 2-18 years. Ann. Nutr. Metab. 76-96. http://dx.doi.org/10.1159/000228997
Valenzuela A, Nieto S. 2001. Ácido dosahexaenoico (DHA) en el desarrollo fetal y en la nutrición maternoinfantil. Rev. Med. Chil. 129, 1-14
Valenzuela A, Nieto S. 2003. Ácidos grasos omega-6 y omega-3 en la nutrición perinatal: su importancia en el desarrollo del sistema nervioso y visual. Rev. Chil. Pediatr. 74, 149-157.
Valenzuela A, Nieto S, Sanhueza J, Morgado N, Rojas I, Zañartu P. 2010. Supplementing female rats with DHA-lysophosphatidylcholine increases docosahexaenoicacido and acetylcholine contents in the brain and improves the memory and learning capabilities of the pups. Grasas Aceites. 61, 16-23. http://dx.doi.org/10.3989/gya.053709
Valenzuela R, Tapia G, González M, Valenzuela A. 2011. Omega-3 fatty acids (EPA and DHA) and its application in diverse clinical situations. Rev. Chil. Pediatr. 38, 356-367.
Vásquez E. 2005. Sucedáneos de la leche materna. SAM Nutrición Pediátrica. Libro 1. Alimentación en el primer Año de Vida. Editores Intersistemas.
Vásquez-Garibay E, Romero-Velarde E. 2008. Esquemas de alimentación saludable en niños durante sus deferentes etapas de la vida. Parte 1. Primeros dos años de vida. Bol. Med. Hosp. Infant. Mex. 65, 593- 604. PMid:19022982
Whelan J. 2008. (n-6) n (n-3) Polyunsaturated Fatty acids and the aging Brain: food for thought. J. Nutr. 138, 2521-2522. http://dx.doi.org/10.3945/jn.108.095943
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