Preparation of stable tea seed oil nano-particle emulsions by a low energy method with non-ionic surfactants
DOI:
https://doi.org/10.3989/gya.1271162Keywords:
Camellia oleifera, Emulsion, Formulation, Self-emulsifying, Stability, Tea seed oilAbstract
Tea seed oil nano-particle emulsions were prepared. Non-ionic surfactants containing Tween 80 and Span 80 (1:1, w/w) were mixed with propanol (3-9:1, w/w) to give Smix, which was thereafter mixed with tea seed oil. The mixture was titrated with water at 150 rpm to give clear or bluish and bluish-white emulsions. Twelve nano-particle emulsions with 64.64 to 72.73% Smix, 16.66 to 27.27% oil and 9.09 to 16.67% water with particle sizes between 207.00 to 430.10 nm, PDI of 0 to 0.4, ζ-potential of -42.00 to -49.63 mV, pH of 7.04 to 7.32 and 151.33 to 241.93 cps, were stable following an accelerated stability test and long term storage at room temperature and 4 and 45 ºC for 90 days, although one system (16.66% oil and 66.67% Smix) was separated. This nano-particle emulsion formulation is concise and feasible for an industrial development of topical products containing tea seed oil.
Downloads
References
Abbsasi S, Radi M. 2016. Food grade microemulsion systems: canolaoil/lecithin:n-propanol/water. Food Chem. 194, 972- 979. https://doi.org/10.1016/j.foodchem.2015.08.078 PMid:26471642
Cheng Y-T, Wu S-L, Ho C-Y, Huang S-M, Cheng C-L, Yen G-C. 2014. Beneficial effects of Camellia oil (Camellia oleifera Abel.) on letoprofen-induced gastrointestinal mucosal damage through upregulation of HO-1 and VEGF. J. Agric. Food Chem. 62, 642-650. https://doi.org/10.1021/jf404614k PMid:24377395
Garti N, Yaghmur A, Leser ME, Clement V, Watzke HJ. 2001. Improved oil solubilization in oil/water food grade microemulsions in the presence of polyols and ethanol. J. Agric. Food Chem. 49, 2552-2562. https://doi.org/10.1021/jf001390b PMid:11368635
Kanlayavattanakul M, Lourith N. 2011. Therapeutic agents and herbs in topical application for acne treatment. Int. J. Cosmet. Sci. 33, 289-297. https://doi.org/10.1111/j.1468-2494.2011.00647.x PMid:21401650
Lee C-P, Yen G-C. 2006. Antioxidant activity and bioactive compounds of tea seed (Camellia oleifera Abel.) oil. J. Agric. Food Chem. 54, 779-784. https://doi.org/10.1021/jf052325a PMid:16448182
Lee C-P, Shih P-H, Hsu C-L, Yen G-C. 2007. Hepatoprotection of tea seed oil (Camellia oleifera Abel.) against CCl4- induced oxidative damage in rats. Food Chem. Toxicol. 45, 888-895. https://doi.org/10.1016/j.fct.2006.11.007 PMid:17188414
Li Y, Zheng J, Xiao H, McClements DJ. 2012. Nanoemulsion-based delivery systems for poorly water-soluble bioactive compounds: influence of formulation parameters on polymethoxyflavone crystallization. Food Hydrocoll. 27, 517- 528. https://doi.org/10.1016/j.foodhyd.2011.08.017 PMid:22685367 PMCid:PMC3367464
Lourith N, Kanlayavattanakul M, Ruktanonchai U. 2016. Formulation and stability of Moringa oleifera oil microemulsion. Soft Matter. 14, 64-71. https://doi.org/10.1080/1539445X.2016.1141786
McClements DJ. 2012. Nanoemulsions versus microemulsions: terminology, differences, and similarities. Soft Matter. 8, 1719-1729. https://doi.org/10.1039/C2SM06903B
Miura D, Kida Y, Nojima H. 2007. Camellia oil and its distillate fractions effectively inhibit the spontaneous metastasis of mouse melanoma BL6 cells. FEBS Lett. 581, 2541-2548. https://doi.org/10.1016/j.febslet.2007.04.080 PMid:17499720
Nazarzadeh E, Anthonypillai T, Sajjadi S. 2013. On the growth mechanisms of nanoemulsions. J. Colloid Interface Sci. 397, 154-162. https://doi.org/10.1016/j.jcis.2012.12.018 PMid:23452515
Odile A-S, L'alloret F, Simonnet J-T. 2001. Nanoemulsion containing nonionic polymers. EP Patent 20010401832.
Polychniatou V, Tzia C. 2014. Study of formulation and stability of co-surfactant free water-in-olive oil nano- and submicron emulsions with food grade non-ionic surfactants. J. Am. Oil Chem. Soc. 91, 79-88. https://doi.org/10.1007/s11746-013-2356-3
Quemin E. 2001. Translucent nanoemulsion, production method, and uses thereof in the cosmetic, dermatological and/or ophthalmological fields. EP Patent 20050013409.
Rao J, McClements DJ. 2012. Lemon oil solubilization in mixed surfactant solutions: rationalizing microemulsion & nanoemulsion formation. Food Hydrocoll. 26, 268-276. https://doi.org/10.1016/j.foodhyd.2011.06.002
Roohinejad S, Oey I, Wen J, Lee SJ, Everett DW, Burritt DJ. 2015. Formulation of oil-in-water ?-carotene microemulsions: effects of oil type and fatty acid chain length. Food Chem. 174, 270-278. https://doi.org/10.1016/j.foodchem.2014.11.056 PMid:25529680
Sahari MA, Ataii D, Hamedi M. 2004. Characteristics of tea seed oil in comparison with sunflower and olive oils and its effect as a natural antioxidant. J. Am. Oil Chem. Soc. 81, 585-588. https://doi.org/10.1007/s11746-006-0945-0
Saraf A. 2010. Applications of novel drug delivery system for herbal formulations. Fitoterapia 81, 680-689. https://doi.org/10.1016/j.fitote.2010.05.001 PMid:20471457
Shafiq S, Shakeel F, Talegaonkar S, Ahmad FJ, Khar RK, Ali M. 2007. Development and bioavailability assessment of ramipril nanoemulsion formulation. Eur. J. Pharm. Biopharm. 66, 227- 243. https://doi.org/10.1016/j.ejpb.2006.10.014 PMid:17127045
Solans C, Solé I. 2012. Nano-emulsions: formation by low-energy methods. Curr. Opin. Colloid Interface Sci. 17, 346-354. https://doi.org/10.1016/j.cocis.2012.07.003
Su MH, Shih MC, Lin K-H. 2014. Chemical composition of seed oils in native Taiwanese Camellia species. Food Chem. 156, 369-373. https://doi.org/10.1016/j.foodchem.2014.02.016 PMid:24629982
Tang B, Cheng G, Gu J, Xu CH. 2008. Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms. Drug Discov. Today 13, 606-612. https://doi.org/10.1016/j.drudis.2008.04.006 PMid:18598917
Wang L, Dong J, Chen J, Eastoe J, Li X. 2009. Design and optimization of a new self-nanoemulsifying drug delivery system. J. Colloid Interface Sci. 330, 443-448. https://doi.org/10.1016/j.jcis.2008.10.077 PMid:19038395
Zhao Y, Wang C, Chow AHL, Ren K, Gong T, Zhang Z, Zheng Y. 2010. Self-nanoemulsifying drug delivery system (SNEDSS) for oral delivery of Zedoary essential oil: formulation and bioavailability studies. Int. J. Pharm. 383, 170-177. https://doi.org/10.1016/j.ijpharm.2009.08.035 PMid:19732813
Published
How to Cite
Issue
Section
License
Copyright (c) 2017 Consejo Superior de Investigaciones Científicas (CSIC)
This work is licensed under a Creative Commons Attribution 4.0 International License.
© CSIC. Manuscripts published in both the print and online versions of this journal are the property of the Consejo Superior de Investigaciones Científicas, and quoting this source is a requirement for any partial or full reproduction.
All contents of this electronic edition, except where otherwise noted, are distributed under a Creative Commons Attribution 4.0 International (CC BY 4.0) licence. You may read here the basic information and the legal text of the licence. The indication of the CC BY 4.0 licence must be expressly stated in this way when necessary.
Self-archiving in repositories, personal webpages or similar, of any version other than the final version of the work produced by the publisher, is not allowed.
