n-3 AGPICL en la reversión de la esteatosis hepática: el papel de la ACOX y CAT
DOI:
https://doi.org/10.3989/gya.0886152Palabras clave:
ACOX (Acil coenzima A oxidasa), AGPICL n-3 (ácidos grasos poliinsaturados de cadena larga omega tres), AP-1 (Proteína activadora 1), CAT-1 (Acil carnitina transferasa 1), DAG (dieta alta en grasa), Enfermedad del hígado graso no alcohólico (EHGNA), Esteatosis hepática, ReversiónResumen
El objetivo de este estudio fue investigar el rol de las enzimas Acil coenzima A oxidasa (ACOX) y Acil carnitina transferasa 1 (CAT-1), además del factor de transcripción, Proteína activadora 1 (AP-1) en la reversión de la esteatosis hepática mediante cambio de dieta más suplementación con Ácidos grasos poliinsaturados de cadena larga omega tres (AGPICL n-3). Ratones macho de la cepa C57BL/6J fueron alimentados con dieta control (DC) o alta en grasas (DAG) durante 12 semanas, luego continuaron con DC con o sin suplementación de AGPICL n-3 durante 8 semanas. Después de este período, se analizó el peso corporal y del tejido adiposo visceral; en las muestras hepáticas se evaluaron los niveles de ACOX, CAT-1 y AP-1. El cambio a dieta control más suplementación con AGPICL n-3 reduce significativamente la esteatosis hepática y la relación tejido adiposo/peso corporal, acompañado de un incremento en los niveles hepáticos de ACOX y CAT-1 y normalización de la expresión de AP-1; regulando la inflamación y favoreciendo la beta oxidación sobre la lipogénesis. Estos resultados proveen nuevos datos sobre el metabolismo enzimático cuando se realiza cambio a dieta control más suplementación con AGPICL n-3.
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