La inmunomodulación como principal característica de los aceites vegetales: revisión
DOI:
https://doi.org/10.3989/gya.1183231.2072Palabras clave:
Aceite de chía, Aceite de linaza, Aceite de oliva, Aceites vegetales, Ácidos grasos insaturados, InmunomodulaciónResumen
Conocidos por ser un alimento funcional, los aceites vegetales son ampliamente utilizados por su actividad nutracéutica. Es de destacar que un tercio de todas las medicinas tradicionales están destinadas a tratar trastornos inflamatorios. Los aceites vegetales están formados básicamente por los ácidos linoleico y alfa-linolénico, que son ácidos grasos poliinsaturados (PUFA) clasificados como esenciales; y los ácidos grasos monoinsaturados (MUFA), como el ácido oleico, que se clasifican como no esenciales. Los aceites de oliva, girasol, linaza y chía son ricos en estos ácidos grasos y sus beneficios están directamente relacionados con el contenido de los mismos. Están comprobados los beneficios de su consumo en la dieta de la población a nivel mundial, promoviendo principalmente el equilibrio del perfil lipídico, aspectos cardiovasculares, disminución de la presión arterial y efectos curativos cuando se usan tópicamente. La mayoría de estos beneficios provienen de los efectos inmunomoduladores de los aceites vegetales, principalmente las actividades antiinflamatorias desencadenadas por los ácidos grasos insaturados presentes en estos aceites.
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Akinkuolie AO, Ngwa JS, Meigs, James B, Djoussé Luc. 2011. Omega-3 polyunsaturated fatty acid and insulin sensitivity: A meta-analysis of randomized controlled trials. Clin. Nutr. 30, 702–707.
Akrami A, Makiabadi E, Askarpour M, Zamani K, Hadi A, Mokari-Yamchi A, Babajafari S, Faghih S, Hojhabrimanesh A. 2020. A Comparative Study of the Effect of Flaxseed Oil and Sunflower Oil on the Coagulation Score, Selected Oxidative and Inflammatory Parameters in Metabolic Syndrome Patients. Clin. Nutr. Res. 9, 63.
Aparicio-Soto M, Sánchez-Hidalgo M, Cárdeno A, Rosillo MÁ, Sánchez-Fidalgo S, Utrilla J, Martín-LacaveI, Alarcón-de-la-Lastra C. 2016. Dietary extra virgin olive oil attenuates kidney injury in pristane-induced SLE model via activation of HO-1/Nrf-2 antioxidant pathway and suppression of JAK/STAT, NF-κB and MAPK activation. J. Nutr. Biochem. 27, 278–288.
Bashir S, Tahir M, Anwar MI, Manzoor F. 2019. Alteration of adipose tissue immune cell milieu towards the suppression of inflammation in high fat diet fed mice by flaxseed oil supplementation. PLoS One 14, 1–13.
Camargo A, Ruano J, Fernandez JM, Parnell LD, Jimenez A, Santos-Gonzalez M, Marin C, Perez-Martinez P, Uceda M, Lopez-Miranda J, Perez-Jimenez F. 2010. Gene expression changes in mononuclear cells in patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil. BMC Genomics 11, 253.
Camell C, Smith CW. 2013. Dietary oleic acid increases M2 macrophages in the mesenteric adipose tissue. PLoS One 8, 1–10.
Carrillo C, Cavia M, Roelofs H, Alonso-Torre, SR. 2011. Cellular physiology biochemistry and biochemistry activation of human neutrophils by oleic acid involves the production of reactive oxygen species and a rise in cytosolic calcium concentration: a comparison with N-6 polyunsaturated fatty acids. Cell. Physiol. Biochem. 28, 329–338.
Casas R, Estruch R, Sacanella E. 2017. The protective effects of extra virgin olive oil on immune-mediated inflammatory responses. Endocrine, Metab. Immune Disord. - Drug Targets18, 23–35.
Cavalli J, Freitas MA, Gonçalves, ECD, Fadanni GP, Santos AA, Raposo NRB, Dutra RC. 2021. Chia oil prevents chemical and immune-mediated inflammatory responses in mice: Evidence for the underlying mechanisms. Food Res. Int. 149, 110703.
Cicerale S, Lucas LJ, Keast RSJ. 2012. Antimicrobial, antioxidant and anti-inflammatory phenolic activities in extra virgin olive oil. Curr. Opin. Biotechnol. 23, 129–135.
Deshpande R, Raina, P, Shinde K, Mansara P, Karandikar M, Kaul-Ghanekar R. 2019. Flax seed oil reduced tumor growth modulated immune responses and decreased HPV E6 and E7 oncoprotein expression in a murine model of ectopic cervical cancer. Prostaglandins Other Lipid Mediat. 143, 106332.
DjuricicI, Calder PC. 2021. Beneficial outcomes of omega-6 and omega-3 polyunsaturated fatty acids on human health: An update for 2021. Nutrients 13, 2421.
DjuricicI, Calder PC. 2022. Polyunsaturated fatty acids and metabolic health: novel insights. Curr. Opin. Clin. Nutr. Metab. Care. 25, 436–442.
Duvall MG, Levy BD. 2016. DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation. Eur. J. Pharmacol. 785, 144–155.
Flori L, Donnini S, Calderone V, Zinnai A, TaglieriI, Venturi F, Testai L. 2019. The nutraceutical value of olive oil and its bioactive constituents on the cardiovascular system. focusing on main strategies to slow down its quality decay during production and storage. Nutrients 11, 1962.
Hogenkamp A, van Vlies N, Fear AL, van Esch BC, Hofman GA, Garssen J, Calder PC. 2011. Dietary fatty acids affect the immune system in male mice sensitized to ovalbumin or vaccinated with influenza. J. Nutr. 141, 698–702.
Imran M, Nadeem M, Manzoor MF, Javed A, Ali Z, Akhtar MN, Ali M, Hussain Y. 2016. Fatty acids characterization, oxidative perspectives and consumer acceptability of oil extracted from pre-treated chia (Salvia hispanica L.) seeds. Lipids Health Dis. 15, 162.
Jeong SK, Park HJ, Park BD, KimI-H. 2010. Effectiveness of topical chia seed oil on pruritus of end-stage renal disease (ESRD) patients and healthy volunteers. Ann. Dermatol. 22, 143.
Jordão Candido C, Silva Figueiredo P, Del Ciampo Silva R, Candeloro Portugal, L, Augusto dos Santos Jaques J, Alves de Almeida, J, de Barros Penteado, B, Albuquerque Dias, D, Marcelino, G, Pott A, Avellaneda Guimarães, RC, Aiko Hiane P. 2019. Protective effect of α-linolenic acid on non-alcoholic hepatic steatosis and interleukin-6 and -10 in Wistar rats. Nutrients 12, 9.
Katsarou AI, Kaliora AC, Papalois A, Chiou A, Kalogeropoulos N, Agrogiannis G, Andrikopoulos NK. 2015. Serum lipid profile and inflammatory markers in the aorta of cholesterol-fed rats supplemented with extra virgin olive oil, sunflower oils and oil-products. Int. J. Food Sci. Nutr. 66, 766–773.
Kerman, BE, Self, W, Yassinea, HN. 2024. Can the gut microbiome inform the effects of omega-3 fatty acid supplementation trials on cognition?Curr Opin Clin Nutr Metab Care 27, 116–124.
Kulczynski B, Kobus-Cisowska J, Taczanowski M, Kmiecik D, Gramza-Michałowska A. 2019. The chemical composition and nutritional value of chia seeds – current state of knowledge. Nutrients 11, 1242–1258.
Kwon Y. 2020. Immuno-resolving ability of resolvins, protectins, and maresins derived from omega-3 fatty acids in metabolic syndrome. Mol. Nutr. Food Res. 64, 1–12.
Lania BG, Morari J, de Almeida AR, da Silva MN, Vieira-Damiani G, de Almeida Lins K, César CL, Velloso LA, Maia NB, Cintra ML, Velho PE, Neves F. 2019. Topical essential fatty acid oil on wounds: Local and systemic effects. PLoS One 14, 1–15.
Masi LN, Martins AR, Rosa Neto JC, Amaral CL, Crisma AR, Vinolo MAR, de Lima Júnior, EA, Hirabara SM, Curi R. 2012. Sunflower oil supplementation has pro-inflammatory effects and does not reverse insulin resistance in obesity induced by high-fat diet in C57BL/6 mice. J. Biomed. Biotechnol. 2012, 1-9.
Mattacks CA, Sadler D, Pond CM. 2004. The effects of dietary lipids on dendritic cells in perinodal adipose tissue during chronic mild inflammation. Br. J. Nutr. 91, 883–892.
Mohamed DA, Mohamed RS, Fouda K. 2020. Anti-inflammatory potential of chia seeds oil and mucilage against adjuvant-induced arthritis in obese and non-obese rats. J. Basic Clin. Physiol. Pharmacol. 31, 1–11.
Monteiro J, Askarian F, Nakamura MT, Moghadasian MH, Ma DWL. 2013. Oils rich in α-linolenic acid independently protect against characteristics of fatty liver disease in the Δ6-desaturase null mouse. Can. J. Physiol. Pharmacol. 91, 469–479.
Ok F, Kaplan HM, Kizilgok B, Demir E. 2020. Protective effect of alpha-linolenic acid on lipopolysaccharide-induced orchitis in mice. Andrologia 52, 6–11.
Parker J, Schellenberger A, Roe A, Oketch-Rabah H, Calderón A. 2018. therapeutic perspectives on chia seed and its oil: a review. Planta Med. 84, 606–612.
Pauls SD, Rodway LA, Winter T, Taylor CG, Zahradka P, Aukema HM. 2018. Anti-inflammatory effects of α-linolenic acid in M1-like macrophages are associated with enhanced production of oxylipins from α-linolenic and linoleic acid. J. Nutr. Biochem. 57, 121–129.
Petraru A, Ursachi F, Amariei S. 2021. Nutritional characteristics assessment of sunflower seeds, oil and cake. perspective of using sunflower oilcakes as a functional ingredient. Plants 10, 2487.
Puertollano MA, Puertollano E, Ruiz‐Bravo A, Jiménez‐Valera M, De Pablo MA, Álvarez De Cienfuegos G. 2004. Changes in the immune functions and susceptibility to Listeria monocytogenes infection in mice fed dietary lipids. Immunol. Cell Biol. 82, 370–376.
Reyes-Quiroz ME, Alba G, Saenz J, Santa-María C, Geniz I, Jiménez J, Ramírez R, Martín-Nieto J, Pintado E, Sobrino F. 2014. Oleic acid modulates mRNA expression of liver X receptor (LXR) and its target genes ABCA1 and SREBP1c in human neutrophils. Eur. J. Nutr. 53, 1707–1717. https://doi.org/10.1007/s00394-014-0677-0
Rodríguez-Cruz M, Cruz-Guzmán OR, Almeida-Becerril T, Solís-Serna AD, Atilano-Miguel S, Sánchez-González JR, Barbosa-Cortés L, Ruíz-Cruz ED, Huicochea JC, Cárdenas-Conejo A, Escobar-Cedillo RE, Yam-Ontiveros CA, Ricárdez-Marcial EF. 2018. Potential therapeutic impact of omega-3 long chain-polyunsaturated fatty acids on inflammation markers in Duchenne muscular dystrophy: A double-blind, controlled randomized trial. Clin. Nutr. 37, 1840–1851.
Ruiz-Lopez N, Usher S, Sayanova OV, Napier JA, Haslam RP. 2015. Modifying the lipid content and composition of plant seeds: engineering the production of LC-PUFA. Appl. Microbiol. Biotechnol. 99, 143–154.
Sales-Campos H, Reis de Souza P, Crema Peghini B, Santana da Silva J, Ribeiro Cardoso C. 2013. An overview of the modulatory effects of oleic acid in health and disease. Mini-Reviews Med. Chem. 13, 201–210.
Tanideh R, Delavari S, Farshad O, Irajie C, Javad Yavari Barhaghtalab M, Koohpeyma F, Koohi‐Hosseinabadi O, Jamshidzadeh A, Tanideh N, Iraji A. 2021. Effect of flaxseed oil on biochemical parameters, hormonal indexes and stereological changes in ovariectomized rats. Vet. Med. Sci. 7, 521–533.
Vaughn AR, Clark AK, Sivamani RK, Shi VY. 2018. Natural oils for skin-barrier repair: ancient compounds now backed by modern science. Am. J. Clin. Dermatol. 19, 103–117.
Watson H, Mitra S, Croden FC, Taylor M, Wood HM, Perry SL, Spencer JA, Quirke P, Toogood GJ, Lawton CL, Dye L, Loadman PM, Hull MA. 2018. A randomised trial of the effect of omega-3 polyunsaturatedfatty acid supplements on the human intestinal microbiota. Gut 67, 1974–1983.
Widmer RJ, Freund MA, Flammer AJ, Sexton J, Lennon R, Romani A, Mulinacci N, Vinceri FF, Lerman LO, Lerman A. 2013. Beneficial effects of polyphenol-rich olive oil in patients with early atherosclerosis. Eur. J. Nutr. 52, 1223–1231.
Yahfoufi N, Alsadi N, Jambi M, Matar C. 2018. The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients 10, 1–23.
Yang J, Wen C, Duan Y, Deng Q, Peng D, Zhang H, Ma H. 2021. The composition, extraction, analysis, bioactivities, bioavailability and applications in food system of flaxseed (Linum usitatissimum L.) oil: A review. Trends Food Sci. Technol. 118, 252–260.
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