Minor components of pomace olive oil enhance VLDL-receptor expression in macrophages when treated with postprandial triglyceride-rich lipoproteins


  • R. Cabello-Moruno Nutrition and Lipid Metabolism. Instituto de la Grasa (CSIC)
  • L. Sinausia Nutrition and Lipid Metabolism. Instituto de la Grasa (CSIC)
  • E. Montero Emergencies Services. General Hospital. HHUU Virgen del Rocío
  • K. M. Botham Department of Comparative Biomedical Sciences, The Royal Veterinary College
  • M. Avella Department of Comparative Biomedical Sciences, The Royal Veterinary College
  • J. S. Perona Nutrition and Lipid Metabolism. Instituto de la Grasa (CSIC)




Macrophages, Pomace olive oil, Postprandial, Triglycerides, VLDL-receptor


Pomace olive oil (POO) is rich in minor components, which can modulate the composition of postprandial triglyceride-rich lipoproteins (TRL) and their uptake by macrophages. The aim of the present study was to investigate the effects of postprandial TRL obtained after the ingestion of meals containing POO or refined olive oil (ROO) on foam cell formation, one of the initial steps of atherogenesis. Meals were administered to 9 healthy men and TRL were isolated from serum 4h after the intake. POO intake led to TRL with lower triglyceride/apo B48 and triglyceride/apo B100 ratios compared to ROO. Upon incubation of THP-1 macrophages with the TRL, an increase in the intracellular triglyceride content and foam cell formation was observed. Compared to ROO-TRL, the only receptor involved in lipoprotein uptake that showed changes in the mRNA expression after treatment with POO-TRL was the VLDL-receptor (VLDLr). In conclusion, the intake of POO modified the composition of human TRL, which increased the VLDLr gene expression in macrophages. However, the changes were not sufficient to enhance foam cell formation.


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How to Cite

Cabello-Moruno R, Sinausia L, Montero E, Botham KM, Avella M, Perona JS. Minor components of pomace olive oil enhance VLDL-receptor expression in macrophages when treated with postprandial triglyceride-rich lipoproteins. grasasaceites [Internet]. 2015Dec.30 [cited 2022Nov.29];66(4):e096. Available from: https://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/1562




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