Effects of diets rich in monounsaturated fatty acids on the management and prevention of insulin resistance: A systematic review

E.L.L.  Ramos; M.F.C.  Lima; A.C.S.F.  Azevedo; M.G.F. Lopes; A.P.B. Moreira; C.T. Souza

doi:10.3989/gya.1125212

Authors

E.L.L. Ramos Research Centre in Nutrients and Physical Exercise Applied to Metabolic Syndrome, Medicine School, Universidade Federal de Juiz de Fora https://orcid.org/0000-0002-3850-6379
M.F.C. Lima Research Centre in Nutrients and Physical Exercise Applied to Metabolic Syndrome, Medicine School, Universidade Federal de Juiz de Fora https://orcid.org/0000-0002-5735-4411
A.C.S.F. Azevedo Research Centre in Nutrients and Physical Exercise Applied to Metabolic Syndrome, Medicine School, Universidade Federal de Juiz de Fora https://orcid.org/0000-0001-8642-8347
M.G.F. Lopes Research Centre in Nutrients and Physical Exercise Applied to Metabolic Syndrome, Medicine School, Universidade Federal de Juiz de Fora https://orcid.org/0000-0003-4035-8448
A.P.B. Moreira Department of Nutrition, Biological Sciences Institute, Universidade Federal de Juiz de Fora https://orcid.org/0000-0001-5909-1996
C.T. Souza Research Centre in Nutrients and Physical Exercise Applied to Metabolic Syndrome, Medicine School, Universidade Federal de Juiz de Fora https://orcid.org/0000-0003-4904-5675

DOI:

https://doi.org/10.3989/gya.1125212

Keywords:

Metabolic syndrome, Monounsaturated fatty acids, Obesity, Systematic review

Abstract

Insulin resistance (IR), which is linked to obesity, is a mechanism associated with metabolic diseases, mainly type 2 diabetes mellitus. Studies have shown that monounsaturated fatty acids (MUFAs) have anti-inflammatory and anti-oxidative properties which positively affect IR. This systematic review examined the effects of MUFAs from different sources on IR in obese or overweight patients with or without metabolic syndrome. A search was carried out in the PubMed/Medline and Bireme/VHL databases, and data from 16 studies were analysed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The intervention time ranged from 1 day to 5.2 years. All participants were overweight or obese; some had central obesity, a moderate risk of cardiovascular disease, low high-density lipoprotein levels, altered fasting glucose levels, prediabetes or type 2 diabetes mellitus. This systematic review provides evidence that MUFA-rich diets can improve IR.

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