Effects of oxidized lipids (4,5 (E)-epoxy-2(E)-heptenal and 4,5 (E)-epoxy-2 (E) -decenal) and lysine reaction products on zinc and calcium utilization: assays in Caco-2 cells

Authors

  • Isabel Seiquer Unidad de Nutrición, Estación Experimental del Zaidín, CSIC
  • María Pilar Navarro Unidad de Nutrición, Estación Experimental del Zaidín, CSIC

DOI:

https://doi.org/10.3989/gya.2003.v54.i4.220

Keywords:

Caco-2 cells, Calcium, Lipid-protein reaction, Oxidized lipids, Zinc

Abstract


The influence of the presence of brown products from the reaction between two oxidized lipids (4,5 (E)-epoxy-2(E)-heptenal, EH, and 4,5 (E)-epoxy-2 (E)-decenal, ED) and lysine (EH-L and ED-L) on zinc and calcium utilization was studied, and compared with a fructosyl-lysine mixture (F-L). Assays were carried out in Caco-2 cells grown in bicameral chambers. The Zn transported across the cell monolayer was significantly lower in the presence of the EH-L, ED-L and F-L samples, specially with EH-L. Significant decreases in Zn uptake were also observed, with no differences between samples. However, calcium transport was no modified. Thus, the assayed lipid-aminoacid brown products seem to have negative effects on Zn availability, whereas Ca availability appears to be unaffected.

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Published

2003-12-30

How to Cite

1.
Seiquer I, Navarro MP. Effects of oxidized lipids (4,5 (E)-epoxy-2(E)-heptenal and 4,5 (E)-epoxy-2 (E) -decenal) and lysine reaction products on zinc and calcium utilization: assays in Caco-2 cells. grasasaceites [Internet]. 2003Dec.30 [cited 2021Dec.5];54(4):350-7. Available from: https://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/220

Issue

Section

Research