Immunomodulation carried out by dietary fatty acids in experimental animals and humans

Authors

  • M. A. de Pablo Martínez Universidad de Jaén, Facultad de Ciencias Experimentales, Departamento de Ciencias de la Salud. Jaén, Spain
  • E. Ortega Morente Universidad de Jaén, Facultad de Ciencias Experimentales, Departamento de Ciencias de la Salud. Jaén, Spain
  • A. Mª Gallego Cabrera Universidad de Jaén, Facultad de Ciencias Experimentales, Departamento de Ciencias de la Salud. Jaén, Spain
  • C. Alvarez Nieto Universidad de Jaén, Facultad de Ciencias Experimentales, Departamento de Ciencias de la Salud. Jaén, Spain
  • G. Alvarez de Cienfuegos López Universidad de Jaén, Facultad de Ciencias Experimentales, Departamento de Ciencias de la Salud. Jaén, Spain

DOI:

https://doi.org/10.3989/gya.2000.v51.i3.478

Keywords:

Diet, Fatty acid, Immunological regulation, Review (paper)

Abstract


Several studies have reported that fatty acids act as modulatory agents of immune response of experimental animals and humans. In this paper, we do and overview of the performed studies by using of unsaturated fatty acids and their influence on several immunitary parameters in studies carried out in vitro as well as ex vivo. It has been shown that unsaturated fatty acids are involved in the reduction of lymphocyte proliferation, cytokine production and natural killer cell activity. On the other hand, in this article we have reviewed the mechanisms by which fatty acids modulate the immune response: I) membrane fluidity alteration; II) production of lipid peroxides; III) eicosanoid production; IV) gene expression modulation.

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Published

2000-06-30

How to Cite

1.
de Pablo Martínez MA, Ortega Morente E, Gallego Cabrera AM, Alvarez Nieto C, Alvarez de Cienfuegos López G. Immunomodulation carried out by dietary fatty acids in experimental animals and humans. grasasaceites [Internet]. 2000Jun.30 [cited 2021Oct.19];51(3):190-5. Available from: https://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/478

Issue

Section

Reviews