Recent advances in lipoprotein and atherosclerosis: A nutrigenomic approach


  • Sergio López Grupo de Nutrición Celular y Molecular, Instituto de la Grasa, CSIC
  • Almudena Ortega Grupo de Nutrición Celular y Molecular, Instituto de la Grasa, CSIC
  • Lourdes Varela Grupo de Nutrición Celular y Molecular, Instituto de la Grasa, CSIC
  • Beatriz Bermúdez Grupo de Nutrición Celular y Molecular, Instituto de la Grasa, CSIC
  • Francisco JG Muriana Grupo de Nutrición Celular y Molecular, Instituto de la Grasa, CSIC
  • Rocío Abia Grupo de Nutrición Celular y Molecular, Instituto de la Grasa, CSIC



Atherosclerosis, Diet, Lipoproteins, Nutrigenomics, Postprandial state, Vascular cells


Atherosclerosis is a disease in which multiple factors contribute to the degeneration of the vascular wall. Many risk factors have been identified as having influence on the progression of atherosclerosis among them, the type of diet. Multifactorial interaction among lipoproteins, vascular wall cells, and inflammatory mediators has been recognised as the basis of atherogenesis. Dietary intake affects lipoprotein concentration and composition providing risk or protection at several stages of atherosclerosis. More intriguingly, it has been demonstrated that the extent to which each lipid or lipoprotein is associated with cardiovascular disease depends on the time to last meal; thus, postprandial lipoproteins, main lipoproteins in blood after a high-fat meal, have been shown to strongly influence atherogenesis. As a complex biological process, the full cellular and molecular characterization of atherosclerosis derived by diet, calls for application of the newly developing “omics” techniques of analysis. This review will considered recent studies using high-throughput technologies and a nutrigenomic approach to reveal the patho-physiological effects that the fasting and postprandial lipoproteins may exert on the vascular wall.


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How to Cite

López S, Ortega A, Varela L, Bermúdez B, Muriana FJ, Abia R. Recent advances in lipoprotein and atherosclerosis: A nutrigenomic approach. Grasas aceites [Internet]. 2009Mar.30 [cited 2024Jul.25];60(1):33-40. Available from:




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