Biochemical appraisal of the underutilized Hura crepitans seed oil: functional and inflammatory responses in albino rats

R.N. Ugbaja; A.O.  Simeon; E.I. Ugwor; S.O. Rotimi; C.O. Eromosele; O. Ademuyiwa

doi:10.3989/gya.0445211

Authors

R.N. Ugbaja Department of Chemical Sciences, Faculty of Science, Augustine University - Department of Biochemistry, College of Biosciences, Federal University of Agriculture https://orcid.org/0000-0003-1456-8900
A.O. Simeon Department of Biochemistry, College of Biosciences, Federal University of Agriculture https://orcid.org/0000-0001-6988-0032
E.I. Ugwor Department of Biochemistry, College of Biosciences, Federal University of Agriculture https://orcid.org/0000-0002-5545-1541
S.O. Rotimi Department of Biological Sciences, College of Science and Technology, Covenant University https://orcid.org/0000-0002-3678-9977
C.O. Eromosele Department of Chemistry, College of Physical Sciences, Federal University of Agriculture https://orcid.org/0000-0002-2192-9834
O. Ademuyiwa Department of Biochemistry, College of Biosciences, Federal University of Agriculture https://orcid.org/0000-0001-8354-1344

DOI:

https://doi.org/10.3989/gya.0445211

Keywords:

Arachis hypogea, Hura crepitans, Inflammation, Organ function, Seed oil

Abstract

Hura crepitans seed oil (HCSO) remains under-utilized, largely due to the scarcity in data regarding its biochemical properties. To investigate the functional and pro-inflammatory responses to HCSO, twenty-four male rats were grouped into four and received compounded diets containing 5%-HCSO; 10%-HCSO; 15%-HCSO; and 15%-AHO (as control) for eight weeks. The functional responses and the expression of pro-inflammatory cytokines and their receptors were appraised. The organ function biomarkers in rats fed with HCSO-supplemented diets were statistically similar to those of control rats, except for uric acid and creatine levels, which were significantly lower in the HCSO-fed groups, and the urea level, which was elevated in all HCSO-fed groups. Also, HCSO significantly downregulated the expression of pro-inflammatory cytokines (TNF-α, IL-1α, IL-1β, and IL-6) and their receptors (IL-1R and IL-6R), when compared to the control group. Our results highlight the reno- and cardio-protective potentials of HCSO, as well as its anti-inflammatory potentials.

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