Investigation on chemical composition, antioxidant activity and SARS-CoV-2 nucleocapsid protein of endemic Ferula longipedunculata Peşmen

A.  Göçeri; İ.  Demirtaş; M.H.  Alma; Ş.  Adem; Z.A.  Kasra; F.  Gül; A.  Uzun

doi:10.3989/gya.0107211

Autores/as

A. Göçeri Department of Bioengineering and Science, Scientific Research Center, Erbil Polytechnic University https://orcid.org/0000-0002-1218-6696
İ. Demirtaş Department of Biochemistry, Faculty of Science and Arts, Igdir University https://orcid.org/0000-0001-8946-647X
M.H. Alma Igdir University https://orcid.org/0000-0001-6323-7230
Ş. Adem Department of Chemistry, Faculty of Sciences, Çankırı Karatekin University https://orcid.org/0000-0003-2146-5870
Z.A. Kasra Department of Bioengineering and Science, Salahaddin University-Erbil https://orcid.org/0000-0002-9762-8093
F. Gül Department of Property, Protection and Security, Igdir Vocational School, Igdir University https://orcid.org/0000-0002-4297-786X
A. Uzun Faculty of Forestry, Department of Forest Botany, Kahramanmaraş Sutcu İmam University https://orcid.org/0000-0002-2577-7460

DOI:

https://doi.org/10.3989/gya.0107211

Palabras clave:

Antioxidante, Composición química, COVID-19, Ferula Longipedunculata Peşmen, SARS-CoV-2

Resumen

Se analizó el aceite esencial y la grasa de la raíz, la parte verde y el tallo de F. Longipedunculata mediante GC-MS y HPLC-TOF/MS y sus actividades antioxidantes (método DPPH) y posible unión de fitoquímicos contra el SARS-CoV-2 nucleocápside utilizando el software Molegro Virtual Docker. En la parte de la raíz de la planta, los componentes prominentes del aceite fueron β-felandreno (53,46%), ocimeno (6,79%), 4-terpineol (5,94%) y santalol (5,03%). Los resultados cuantitativos mostraron los siguientes valores: ácido vainílico (141,35 mg/kg), ácido ferúlico (126,19 mg/kg) y ácido 4-hidroxibenzoico (119,92 mg/kg) en la raíz, quercetina-3-β-O-glucósido (1737,70 mg/kg), quercetina (531,35 mg/kg) y ácido ferúlico (246,22 mg/kg) en la parte verde y ácido fumárico (2100,21 mg/kg), quercetina-3-β-O-glucósido (163,24 mg/kg) y ácido vainílico (57,59 mg/kg) en la parte del tallo, respectivamente. La actividad antioxidante de todas las partes de la planta fue mayor que el control de BHT. La silibinina, la rutina y la neohesperidina exhibieron una afinidad más fuerte que los nucleótidos. En el análisis silico, muchos de los fitoquímicos se pueden unir con fuertes enlaces de hidrógeno y con efectos electrostáticos a los aminoácidos a los que se unen los nucleótidos. Los resultados indicaron que la planta tiene un efecto antioxidante y puede ser eficaz contra el SARS-CoV-2 gracias a los diferentes compuestos fitoquímicos que contiene.

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