Antioxidant activity of flower, stem and leaf extracts of Ferula gummosa Boiss
DOI:
https://doi.org/10.3989/gya.110809Keywords:
Antihemolytic, Antioxidant activity, Ferula gummosa, FlavonoidAbstract
The Antioxidant and antihemolytic activities of hydroalcoholic extracts of the flowers, stems and leaves of the Ferula gummosa Boiss were investigated employing different in vitro assay systems. Leaf extract showed better activity in DPPH radical scavenging. In addition it showed better activity in nitric oxide and H2O2 scavenging and Fe2+ chelating activity than the other parts. The extracts exhibited good antioxidant activity in linoleic acid system test but were not comparable with vitamin C (p< 0.001). The extracts showed weak reducing power activity. The F. gummosa stem extract showed better antihemolytic activity against H2O2 induced hemolysis. Among the extracts, the flowers had higher phenolic and flavonoid contents. This plant is very promising for further biochemical experiments.
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Chaudhuri S, Banerjee A, Basu K, Sengupta B, Sengupta PK. 2007. Interaction of flavonoids with red blood cell membrane lipids and proteins: Antioxidant and antihemolytic effects. Int. J. Biol. Macromol. 41, 42-48. doi:10.1016/j.ijbiomac.2006.12.003 PMid:17239435
Dehpour AA, Ebrahimzadeh MA, Nabavi SF, Nabavi SM. 2009. Antioxidant activity of the methanol extract of Ferula assafoetida and its essential oil composition. Grasas y Aceites 60, 405-412. doi:10.3989/gya.010109
Dunnik JK, Hailey JR.1992. Toxicity and carcinogenicity studies of quercetin, a natural component of foods. Fundam. Appl. Toxicol. 19, 423-431. doi:10.1016/0272-0590(92)90181-G
Duh PD, Tu YY, Yen GC. 1999. Antioxidant activity of water extract of harng Jyur (Chrysanthemum morifolium Ramat). Lebensm. Wiss Technol. 32, 269–277. doi:10.1006/fstl.1999.0548
Ebrahimzadeh MA, Pourmorad F, Bekhradnia AR. 2008a. Iron chelating activity screening, phenol and flavonoid content of some medicinal plants from Iran. Afr. J. Biotech. 7, 3188-3192.
Ebrahimzadeh MA, Pourmorad F, Hafezi S. 2008b. Antioxidant Activities of Iranian Corn Silk. Turk. J. Biol. 32, 43-49.
Ebrahimzadeh MA, Bahramian F. 2009a. Antioxidant activity of Crataegus pentagina subsp . elbursis Fruits extracts used in traditional medicine in Iran. Pak. J. Boil. Sci. 12, 413-419. doi:10.3923/pjbs.2009.413.419 PMid:19579980
Ebrahimzadeh MA, Ehsanifar S, Eslami B. 2009b. Sambucus ebulus elburensis fruits: A good source for antioxidants. Pharmacognosymagazine 4, 213-218.
Ebrahimzadeh MA, Nabavi SF, Nabavi SM. 2009c. Antioxidant activities of methanol extract of sambucus ebulus L. flower . Pak. J. Biol. Sci. 12, 447-450. doi:10.3923/pjbs.2009.447.450 PMid:19579986
Ebrahimzadeh MA, Nabavi SF, Nabavi SM. 2009d. Antihemolytic and antioxidant activity of hibiscus esculentus leaves. Pharmacologyonline 2, 1097-1105.
Ebrahimzadeh MA, Nabavi SF, Nabavi SM. 2009e. Essential oil composition and antioxidant activity of Pterocarya fraxinifolia. Pak. J. Biol Sci. 12, 957-963. doi:10.3923/pjbs.2009.957.963
Ebrahimzadeh MA, Nabavi SM, Nabavi SF. 2009f. Correlation between the in vitro iron chelating activity and poly phenol and flavonoid contents of some medicinal plants. Pak. J. Biol. Sci. 12, 934-938. doi:10.3923/pjbs.2009.934.938
Ebrahimzadeh MA, Nabavi SM, Nabavi SF, Eslami B. 2009g. Free radical scavenging ability of methanolic extract of hyoscyamus squarrosus leaves. Pharmacologyonline 2, 796-802.
Ebrahimzadeh MA, Nabavi SM, Nabavi SF, Eslami B, Ehsanifar S. 2009h. Antioxidant activity of Hyoscyamus squarrosus fruits. Pharmacologyonline 2,644-650.
Ebrahimzadeh MA, Nabavi SM, Nabavi, SF, Eslami B.2009i. Antioxidant activity of aqueous extract of Pyrus boissieriana fruit. Pharmacologyonline 1, 1318-1323.
Ebrahimzadeh MA, Nabavi SF, Nabavi SM, Eslami B. 2010. Antihypoxic and antioxidant activity of Hibiscus esculentus seeds. Grasas y Aceites 61, 30-36. doi:10.3989/gya.053809
Eftekhar F, Yousefzadi M, Borhani K. 2004. Antibacterial activity of the essential oil from Ferula gummosa seed. Fitoterapia 75, 758–759. doi:10.1016/j.fitote.2004.09.004 PMid:15567258
Esmaeili A, Tavassoli A, Ebrahimzadeh MA. 2009. Antioxidant activity and free radical scavenging activity of Salvia glutiosa growing in Iran. Pharmacologyonline 2, 109-116.
Fazly Bazaz BS, Parsaei H, Haririzadeh G, Shoshtari AN.1997. Evaluation of antinociceptive and antimicrobial activities of galbanum plant (Ferula gummosa). Daru 7, 1-22.
Ghasemi K, Ghasemi Y, Ebrahimzadeh MA. 2009. Antioxidant activity, phenol and flavonoid contents of 13 Citrus species peels and tissues. Pak. J. Pharm. Sci. 22, 277-281. PMid:19553174
Ghosal S, Tripathi VK, Chauhan S.1996. Active constituents of Emblica officinalis. Part I. The chemistry and antioxidant effects of two new hydrolysable tannins, emblicanin A and B. Ind. J. Chem. 35B, 941-948.
Grazul M, Budzisz E. 2009. Biological activity of metal ions complexes of chromones, coumarins and flavones. Coordin. Chem. Rev. 253, 2588-2598. doi:10.1016/j.ccr.2009.06.015
Halliwell B, Gutteridge JMC. 1990. Role of free radicals and catalytic metal ions in human disease: an overview. Method Enzymol. 186, 1-85. doi:10.1016/0076-6879(90)86093-B
Halliwell B.1994. Free radicals, antioxidants and human diseases; curiosity, cause or consequence? Lancet 334, 721-724. doi:10.1016/S0140-6736(94)92211-X
Halliwell B. 1997. Antioxidants: the basics- what they are and how to evaluate them. Adv. Pharmacol. 38, 3–20. doi:10.1016/S1054-3589(08)60976-X
Hebbel RP, Leung A, Mohandas N. 1990. Oxidationinduced changes in microheological properties of the red cell membrane. Blood 76, 1015-1022. PMid:2393710
Mandegary A, Sayyah M, Heidari MR. 2004. Antinociceptive and anti-inflammatory activity of the seed and root extracts of Ferula gummosa Boiss in mice and rat. Daru 12, 58-62.
Moncada A, Palmer RMJ, Higgs EA. 1991. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev. 43, 109-142. PMid:1852778
Nabavi SM, Ebrahimzadeh MA, Nabavi SF, Hamidinia A, Bekhradnia AR. 2008a. Determination of antioxidant activity, phenol and flavonoids content of Parrotia persica Mey. Pharmacologyonline 2, 560-567.
Nabavi SM, Ebrahimzadeh MA, Nabavi SF and Jafari M. 2008b. Free radical scavenging activity and antioxidant capacity of Eryngium caucasicum Trautv and Froriepia subpinnata. Pharmacologyonline 3, 19-25.
Nabavi SM, Ebrahimzadeh MA, Nabavi SF, Bahramian F. 2009a. Invitro antioxidant activity of Phytolacca americana berries. Pharmacologyonline 1, 81-88.
Nabavi SM, Ebrahimzadeh MA, Nabavi SF, Fazelian M, Eslami B. 2009b. In vitro Antioxidant and free radical scavenging activity of Diospyros lotus and Pyrus boissieriana growing in Iran. Pharmacognosy magazine 4, 123-127.
Ramezani M, Hosseinzadeh H, Mojtahedi K. 2001. Effect of Ferula gummosa Boiss. fractions on morphine dependence in mice. J. Ethnopharmacol 77, 71-75. doi:10.1016/S0378-8741(01)00263-X
Sadraei H, Asghari GR, Hajhashemi V, Kolagar A, Ebrahimi M. 2001. Spasmolytic activity of essential oil and various extracts of Ferula gummosa Boiss. on ileum contractions. Phytomedicine 8, 370–376. doi:10.1078/0944-7113-00052 PMid:11695880
Sadrazadeh SMH, Graf E, Panter SS, Hallaway PE, Eaten JW. 1984. Hemoglobin, a biological Fenton reagent. J. Biol.Chem. 259, 14354-14356.
Sayyah M, Kamalinejad M, Bahrami Hidage R, Rustaiyan A. 2001. Antiepileptic potential and composition of the fruit essential oil of Ferula gummosa boiss. Iran Biomed. J. 5, 69-72.
Sayyah M, Mandgary A, Kamalinejad M. 2002. Evaluation of the anticonvulsant activity of the seed acetone extract of Ferula gummosa Boiss against seizures induced by pentylenetetrazole and electroconvulsive shock in mice. J. Ethnopharmacol. 82,105-109. doi:10.1016/S0378-8741(02)00166-6
Shah V, Lyford G, Gores G, Farrugia G. 2004. Nitric oxide in gastrointestinal health and disease. Gastroenterology 126, 903-913. doi:10.1053/j.gastro.2003.11.046 PMid:14988844
Van Acker SABE, van Den Berg DJ, Tromp MNJL, Griffioen DH, Van Bennekom WP, van der Vijgh WJF, et al. 1996. Structural aspects of antioxidant activity of flavanoids. Free Radical Bio. Med. 20, 331–342. doi:10.1016/0891-5849(95)02047-0
Yang HL, Chen SC, Chang NW, Chang JM, Lee ML, Tasi PE, Fu HH, Kao WW, Chiang HC, Wang HH, Hseu YC. 2006. Protection from oxidative damage using Bidens pilosa extracts in normal human erythrocytes. Food Chem. Toxicol. 44, 1513-1521. doi:10.1016/j.fct.2006.04.006 PMid:16765500
Yu LL. 2001. Free radical scavenging properties of conjugated linoleic acids. J. Agr. Food Chem. 49, 3452–3456. doi:10.1021/jf010172v PMid:11453790
Yuan X, Wang J, Yao H, Chen F. 2005. Free radicalscavenging capacity and inhibitory activity on rat erythrocyte hemolysis of feruloyl oligosaccharides from wheat bran insoluble dietary fiber. LWT-Food Sci. Technol. 38, 877-883.
Zargari A. 1991. Medicinal Plants. Vol. 2. Tehran: Tehran University Publication. pp. 598-602.
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