Potential of <em>Annona muricata</em> L. seed oil: phytochemical and nutritional characterization associated with non-toxicity

L. C. Pinto; C. O. de Souza; S. A. de Souza; H. B. da Silva; R. R. da Silva; A. T. Cerqueira-Lima; T. O. Teixeira; T. M.S. da Silva; K. C.P. Medeiros; M. Bittencourt; H. R. Brandão; J. I. Druzian; A. S. Conceição; M. V. Lopes; C. A. Figueiredo

doi:10.3989/gya.0777171

Authors

L. C. Pinto Department of Food Science, School of Nutrition, Federal University of Bahia https://orcid.org/0000-0001-7470-7074
C. O. de Souza Faculty of Pharmacy, Federal University of Bahia https://orcid.org/0000-0002-8028-5418
S. A. de Souza Laboratory of Phytochemistry Bioprospecting, Federal Rural University of Pernambuco https://orcid.org/0000-0001-9689-7614
H. B. da Silva Institute of Health Sciences, Federal University of Bahia https://orcid.org/0000-0003-1585-9099
R. R. da Silva Department of Life Sciences, State University of Bahia https://orcid.org/0000-0002-3422-0453
A. T. Cerqueira-Lima Institute of Health Sciences, Federal University of Bahia https://orcid.org/0000-0001-7991-4005
T. O. Teixeira Institute of Health Sciences, Federal University of Bahia https://orcid.org/0000-0001-7998-2569
T. M.S. da Silva Laboratory of Phytochemistry Bioprospecting, Federal Rural University of Pernambuco https://orcid.org/0000-0003-1887-2598
K. C.P. Medeiros Federal University of Rio Grande do Norte https://orcid.org/0000-0002-7784-0740
M. Bittencourt Veterinary Hospital UNIME (HOSVET). Metropolitan Union of Education and Culture (UNIME) https://orcid.org/0000-0002-9893-173X
H. R. Brandão Veterinary Hospital UNIME (HOSVET). Metropolitan Union of Education and Culture (UNIME) https://orcid.org/0000-0001-9061-7749
J. I. Druzian Faculty of Pharmacy, Federal University of Bahia https://orcid.org/0000-0001-8940-6098
A. S. Conceição University of Bahia State, Department of Education, Herbarium of the State University of Bahia (HUNEB) https://orcid.org/0000-0002-8800-422X
M. V. Lopes Department of Life Sciences, State University of Bahia https://orcid.org/0000-0001-5985-8755
C. A. Figueiredo Institute of Health Sciences, Federal University of Bahia https://orcid.org/0000-0003-1356-6188

DOI:

https://doi.org/10.3989/gya.0777171

Keywords:

Acetogenins, Annona muricata seeds, Annonacin, Linoleic acid, Oleic acid

Abstract

The aim of this study was to evaluate the nutritional quality, phenolic compounds, fatty acid and antioxidant activity in vitro as well as a toxicological screening of A. muricata seed oil in vivo. The chemical composition and quantification of phenolic compounds were determined by the Adolfo Lutz Institute normative. The antioxidant activity was evaluated by DPPH, FRAP and ABTS methods. The oil was extracted by chloroform/ methanol and precipitated crude (AmPtO) and supernatant oils (AmSO) were obtained. The fatty acid profile was evaluated by gas chromatography and total compounds by HPLC-DAD. BALB/C mice received AmPtO and AmSO (0.5 and 1.0mL·Kg^-1) for 14 days. Toxicity parameters were assessed. The major fatty acids in the oil were oleic (39.2%) and linoleic (33%). HPLC-DAD suggested the presence of acetogenins (annonacin: 595 [M-H]-), with a greater presence in AmPtO. The AmPtO group showed toxicity, which may be related to the acetogenin content in AmPtO. The AmSO group showed no toxicity and this oil has potential for food or medicinal use.

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