Antioxidant and anticancer activities of peanut (Arachis hypogaea L.) skin ultrasound extract

K.S.M. Hammad; A.M. El-Roby; S.M. Galal

doi:10.3989/gya.0990221

Autores/as

K.S.M. Hammad Department of Food Science, Faculty of Agriculture, Cairo University https://orcid.org/0000-0003-4983-7920
A.M. El-Roby Department of Food Science, Faculty of Agriculture, Cairo University https://orcid.org/0000-0002-2065-5405
S.M. Galal Department of Food Science, Faculty of Agriculture, Cairo University https://orcid.org/0000-0002-1859-1641

DOI:

https://doi.org/10.3989/gya.0990221

Palabras clave:

Aceite de girasol, Anticancerígeno, Antioxidante, Extracción asistida por ultrasonido, Piel de maní, Polifenoles

Resumen

Este estudio evalúa el efecto de la extracción asistida por ultrasonido sobre la extractabilidad de los polifenoles de la piel de maní (PS) y sus actividades antioxidantes y anticancerígenas. La extracción se realizó con relaciones sólido/solvente de 1:20 y 1:30 (p/v) a una intensidad de ultrasonido que varió de 5,8 a 15,4 W/cm² para diferentes tiempos de extracción (10, 20, 30 y 40 min). El mayor rendimiento de polifenoles fue de 167,46 mg GAE/g de PS seco. Los polifenoles más abundantes fueron la catequina, el ácido siríngico y el ácido vanílico. El extracto de ultrasonido PS (PSUE) aumentó cuatro veces la estabilidad oxidativa del aceite de girasol. PSUE poseía una alta actividad inhibitoria contra las líneas celulares de cáncer MCF-7, HepG-2, HCT-116 y PC-3, con IC50 que oscilaba entre 1,85 ± 0,13 y 6,1 ± 0,43 μg/ml. Además, se examinó la citotoxicidad de PSUE en melanocitos humanos normales HFB4 utilizando el ensayo MTT. Estos resultados sugieren que el PSUE puede usarse como un antioxidante natural y un agente anticancerígeno.

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