Antioxidant, anti-inflammatory and cytotoxic activities of the unsaponifiable fraction of extra virgin olive oil

M. M. Elaasser; M. K.S. Morsi; S. M. Galal; M. K. Abd El-Rahman; M. A. Katry

doi:10.3989/gya.0916192

Autores/as

M. M. Elaasser The Regional Center for Mycology and Biotechnology, Al-Azhar University https://orcid.org/0000-0003-0862-7628
M. K.S. Morsi Department of Food Science, Faculty of Agriculture, Cairo University https://orcid.org/0000-0003-2061-6075
S. M. Galal Department of Food Science, Faculty of Agriculture, Cairo University https://orcid.org/0000-0002-1859-1641
M. K. Abd El-Rahman National Nutrition Institute, Ministry of Health and Population https://orcid.org/0000-0003-0474-3023
M. A. Katry National Nutrition Institute, Ministry of Health and Population https://orcid.org/0000-0002-2857-671X

DOI:

https://doi.org/10.3989/gya.0916192

Palabras clave:

Aceite de oliva, Antiinflamatorio, Antioxidante, Citotoxicidad, Fracción insaponificable

Resumen

Los beneficios para la salud del aceite de oliva son bien conocidos. En este estudio, se investigó la fracción insaponificable del aceite de oliva virgen extra (Insap) para reducir el poder antioxidante férrico, la actividad quelante ferrosa y la inhibición del óxido nítrico. El presente estudio también fue diseñado para evaluar el efecto citotóxico in vitro del Insap contra las células de carcinoma humano. La potencialidad antiinflamatoria del Insap se ha determinado mediante la inhibición de las ciclooxigenasas humanas. Los resultados mostraron que el Insap es eficiente para reducir el poder antioxidante férrico y la inhibición del óxido nítrico. El Insap tiene un efecto selectivo como agente antiinflamatorio. Los resultados mostraron actividades antitumorales in vitro del Insap de moderadas a buenas contra células de cáncer de hígado, pulmón y páncreas humano con una CI50 que varía de 19,6 a 30,4 μg/ml y por su buen índice de selectividad ( ≥ 2). En conclusión, el Insap contiene material antitumoral y antioxidante prometedor y seguro que será respaldado por investiga-ciones adicionales.

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Citas

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