Chemical composition, oxidative stability and antiproliferative activity of <em>Anethum graveolens</em> (dill) seed hexane extract

I. A. Nehdia; N. Abutaha; H. M. Sbihi; C. P. Tan; S. I. Al-Resayes

doi:10.3989/gya.0455191

Autores/as

I. A. Nehdia Chemistry Department, College of Science, King Saud University - Chemistry Department, Science College, Tunis El Manar University. https://orcid.org/0000-0001-9312-4683
N. Abutaha Bioproducts Researach Chair, Zoology Department, College of Science, King Saud University https://orcid.org/0000-0002-1887-7789
H. M. Sbihi Chemistry Department, College of Science, King Saud University https://orcid.org/0000-0002-0249-1224
C. P. Tan Department of Food Technology, Faculty of Food Science and Technology, Universiti Putra Malaysia https://orcid.org/0000-0003-4177-4072
S. I. Al-Resayes Chemistry Department, College of Science, King Saud University https://orcid.org/0000-0002-2498-3609

DOI:

https://doi.org/10.3989/gya.0455191

Palabras clave:

Actividad antiproliferativa, Anethum graveolens, Compuestos volátiles, Estabilidad oxidativa, Extracto con hexano de semilla de eneldo, Propiedades térmicas

Resumen

Este estudio tuvo como objetivo evaluar las propiedades fisicoquímicas, la composición química y la actividad antiproliferativa del extracto de hexano de semillas de Anethum graveolens L. (eneldo) mediante cromatografía de gases con espectrometría de masas (GC-MS). Se detectaron dos fracciones, la fracción lipídica (74%) y la fracción volátil (26%). El contenido del extracto de las semillas fue de aproximadamente 9,4% y el extracto tenía un agradable aroma picante. Los ácidos oleico (52%), cis-vaccénico (6,2%), linoleico (5,5%) y palmítico (3,3%) fueron los ácidos grasos clave en la fracción lipídica, mientras que el apiol (23%) y la d-carvona (2,4%) fueron los principales componentes volátiles. También se detectaron tocoles (tocoferoles y tocotrienoles) en el extracto de A. Graveolens (155 mg/100 g) y se identificó el β-tocoferol como el principal tocol (71%). El extracto de eneldo mostró una alta estabilidad oxidativa (tiempo de inducción = 45,22 h). Además, el extracto de eneldo mostró actividad antiproliferativa contra las líneas celulares de cáncer de mama.

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