Stearic acid: a possible substitute for trans fatty acids from industrial origin
DOI:
https://doi.org/10.3989/gya.033910Keywords:
Alternatives to hydrogenated fats, Cardiovascular health, “Neutral” metabolic effect, Stearic acid, trans IsomersAbstract
Trans isomers, contained in partially hydrogenated oils, which are used in the food industry, have been questioned and nowadays trends are heading towards reducing their consumption. The food industry is facing a dilemma, since in order to remove trans fatty acids, hydrogenated fats should be eliminated and replaced by fats rich in saturated fatty acids. Scientific research has shown that saturated fatty acids have negative effects on the lipid profile and its consumption is associated with a higher cardiovascular risk. Therefore it is recommended to avoid their consumption. Nevertheless, not all fatty acids behave in the same way, with stearic acid (18:0) the exception. Stearic acid has a low level of intestinal absorption and its intake does not negatively modify the lipid profile. For this reason, it is considered a “neutral” fatty acid with regard to cardiovascular health. B-100 apolipoprotein, whose levels determine plasma VLDL and LDL concentration (triglycerides and cholesterol carriers, respectively), is not modified by diets which provide up to 7% of the energy as stearic acid. Markers of cardiovascular risk, such as activation of platelet aggregation factors or C-reactive protein levels, are not modified by diets providing stearic acid, as occurs with other saturated fatty acids. The confirmation of the “neutral” effect of stearic acid represents a perspective for the development of fats with high contents of this fatty acid to replace hydrogenated fats containing trans isomers. The present review discusses these aspects.
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Allison DB, Egan SK, Barraj LM, Caughman C, Infante M, Heimbach JT. 1999. Estimated intakes of trans fatty acids and other fatty acids in the US population. J. Am. Diet. Assoc. 99, 166-174. doi:10.1016/S0002-8223(99)00041-3
Aro A, Jauhiainen M, Partenen R, Salminen L, Mutanen M. 1997. Stearic acid, trans fatty acids, and dairy fat: effects on serum and lipoprotein lipids, apolipoproteins, lipoprotein(a), and lipid transfer protein in healthy subjects. Am. J. Clin. Nutr. 65, 1419-1426. PMid:9129471
Aro A. 2005. The scientific basis of TFA regulationsis it sufficient? A personal view. First International Symposium on Trans fatty Acids and Health. Rungstedgaard, Denmark, September 11-13, Abstract.
Ascherio A, Rimm EB, Giovannucci EL, Spiegelman D, Stampfer M, Willett WC. 1996. Dietary fats and risk of coronary heart disease in men: cohort follow up study in the United States. Brit. Med. J. 313, 84-90. PMid:8688759 PMCid:2351515
Baer DJ, Judd JT, Kris-Etherton PM, Zhao G, Emken EA. 2003. Stearic acid absorption and its metabolizable energy value are minimally lower than those of other fatty acids in healthy men fed mixed diets. J. Nutr. 133, 4129-4134. PMid:14652360
Baer DJ, Judd J, Clevidence B, Tracy R. 2004. Dietary fatty acids affect plasma markers of inflammation in healthy men fed controlled diets: a randomized crossover study. Am. J. Clin. Nutr. 79, 969-973. PMid:15159225
Berry SE, Sanders TA. 2005. Influence of triacylglyceride structure of stearic acid-rich fats on postprandial lipaemia. Proc. Nutr. Soc. 64, 205-212. doi:10.1079/PNS2005422 PMid:15960865
Berry SE, Miller GJ, Sanders TA. 2007. The solid fat content of stearic acid-rich fats determines their postprandial effects. Am. J. Clin. Nutr. 85, 1486-1494. PMid:17556683
Blake GJ, Ridker PM. 2002. Inflammatory biomarkers and cardiovascular risk prediction. J. Intern. Med. 252, 283-294. doi:10.1046/j.1365-2796.2002.01019.x PMid:12366601
Bracco U. 1994. Effect of triglyceride structure on fat absorption. Am. J. Clin. Nutr. 60, 1002S-1009S. PMid:7977140
Carroll KK. 1958. Digestibility of individual fatty acids in the rat. J. Nutr. 64, 399-410. PMid:13526018
Christie WW, Moore JH. 1972. The structure of adipose tissue and heart muscle triglycerides in the domestic chicken (Gallus gallus). J. Sci. Food Agric. 23, 73-77. doi:10.1002/jsfa.2740230110 PMid:5028299
Clevidence BA, Judd JT, Schaefer EJ. 1997. Plasma lipoprotein (a) levels in men and women consuming diets enriched in saturated cis or transmonounsaturated fatty acids. Arterioescler. Thromb. Vasc. Biol. 17, 1657-1661. PMid:9327759
Craig-Schmidt M. 2006. World-wide Consumption of trans fatty acids. Atherosclerosis (suppl) 7, 1-4. doi:10.1016/j.atherosclerosissup.2006.04.001 PMid:16713396
Daumerie CM, Woollett LA, Dietschy JM. 1992. Fatty acids regulate hepatic low density lipoprotein receptor activity through redistribution of intracellular cholesterol pool. Proc. Natl. Acad. Sci. USA. 89, 10797-10801. doi:10.1073/pnas.89.22.10797
Ding E, Hutfless S, Ding X, Girotra S. 2006. Chocolate and prevention of cardiovascular disease: a systematic review. Nutrition & Metabolism, 3, 2-14.
Di Rienzo MA, Lemke SL, Petersen BJ, Smith KM. 2008. Effect of substitution of high stearic acid low linolenic acid soybean oil for hydrogenated soybean oil on fatty acid intake. Lipids 43, 451-456. doi:10.1007/s11745-008-3173-6 PMid:18365266
Eckel RH, Borra S, Lichtenstein AH, Yin-Piazza SY. 2007. Understanding the complexity of trans fatty acid reduction in the American diet. Circulation 115, 2231-2246. doi:10.1161/CIRCULATIONAHA.106.181947 PMid:17426064
Ervin RB, Wright JD, Wang CY, Kennedy-Stephenson J. 2004. Dietary intake of fats and fatty acids for the United States population: 1999-2000. Adv. Data (November 8), 1-6.
Finley J, Klemann L, Levielle G, Otterburn M, Walchak C. 1994. Caloric availability of SALATRIM in rats and humans. J. Agric. Food Chem. 42, 495-499. doi:10.1021/jf00038a046
Gardner CD, Fortmann SP, Krauss RM. 1996. Association of small low density lipoproteins particles with the incidence of coronary artery disease in men and women. Jama 276, 875-881. doi:10.1001/jama.276.11.875 PMid:8782636
Garg ML. 1992. Stearic Acid Desaturation and incorporation into murine peritoneal macrophage lipids. J. Clin. Biochem. Nutr. 13, 169-178.
German JB, Dillard CJ. 2004. Saturated fats: what dietary intake?. Am. J. Clin. Nutr. 80, 550-559. PMid:15321792
Hassel CA, Mensing E, Gallaher D. 1997. Dietary stearic acid reduces plasma and hepatic cholesterol concentration without increasing bile acid excretion in cholesterol-fed hamsters. J. Nutr. 127, 1148-1155. PMid:9187629
Hegsted DM, McGandy RB, Myers ML, Stare FJ. 1965. Quantitative effects of dietary fat on serum cholesterol in man. Am. J. Clin. Nutr. 17, 281-295. PMid:5846902
Hu F, Stampfer M, Manson J, Rimm E, Colditz G, Rosner B, Hennekens C, Willett W. 1997. Dietary fat intake and the risk of coronary heart disease in women. N. Engl. J. Med. 337, 1491-1499. doi:10.1056/NEJM199711203372102 PMid:9366580
Hunter JE. 2001. Studies on effects of dietary fatty acids as related to their position on triglycerides. Lipids 36, 655-668. doi:10.1007/s11745-001-0770-0 PMid:11521963
Hunter JE. 2006. Dietary trans fatty acids: a review of recent human studies and food industry responses. Lipids 41, 967-992. doi:10.1007/s11745-006-5049-y PMid:17263298
Hunter JE, Zhang J, Kris-Etherton P. 2010. Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: a systemic review. Am. J. Clin. Nutr. 91, 46-63. doi:10.3945/ajcn.2009.27661 PMid:19939984
Hutshof K, Van Erp-Baart MA, Anttolainen M. 1999. Intake of fatty acids in western Europe with emphasis on trans fatty acids: the TRANSFAIR study. Eur. J. Clin. Nutr. 53, 143-57. doi:10.1038/sj.ejcn.1600692 PMid:10099948
Imaizumi K, Abe K, Kuroiwa C, Sugano M. 1993. Fat containing stearic acid increases fecal neutral steroid excretion and catabolism without affecting plasma cholesterol concentration in hamsters fed a cholesterol-containing diet. J. Nutr. 123, 1683-1702.
Judd JT, Clevidence DJ, Kris-Etherton P, Muesing R A, Iwane N. 2002. Dietary cis and trans monounsaturated and saturated fatty acids and plasma lipids and lipoprotein in men. Lipids, 37, 123-131. doi:10.1007/s11745-002-0871-9 PMid:11908904
Keys A, Anderson JT, Grande F. 1965. Serum cholesterol response to changes in the diet IV. Particular saturated fatty acids in the diet. Metabolism 14, 776-787. doi:10.1016/0026-0495(65)90004-1
Korver O, Katan M. 2006. The elimination of trans fats from spreads: how science helped to turn an industry around. Nutr. Rev. 64, 275-279. PMid:16808113
Kris-Etherton P, Yu S. 1997. Individual fatty acid effects on plasma lipids and lipoproteins: human studies. Am. J. Clin. Nutr. 65, 1628S-1644S. PMid:9129503
Kris-Etherton PM, Griel AE, Psota TL, Gebauer S K, Zhang J, Etherton TD. 2005. Dietary stearic acid and risk of cardiovascular disease: intake, sources, digestion, and absorption. Lipids, 40, 1193-1200. doi:10.1007/s11745-005-1485-y PMid:16477802
Kritchevsky D. 1994. Stearic acid and atherogenesis: history. Am. J. Clin. Nutr. 60, 997S-1001S. PMid:7977159
Kromhout D, Menotti A, Bloemberg B. 1995. Dietary saturated and trans fatty acids and cholesterol and 25-year mortality from coronary heart disease: The Seven Countries Study. Prev. Med. 24, 308-315. doi:10.1006/pmed.1995.1049 PMid:7644455
Kubow S. 1996. The influence of positional distribution of fatty acids in native, interesterified and structurespecific lipids on lipoprotein metabolism and atherogenesis. J. Nutr. Biochem. 7, 530-541. doi:10.1016/S0955-2863(96)00106-4
Larqué E, Zamora S, Gil A. 2001. Dietary trans fatty acids in early life: a review. Early Human Develop. 65, S31-S41. doi:10.1016/S0378-3782(01)00201-8
Leth T, Bysted A, Erendah-Mikkelsen A. 2005. The effect of the regulation on trans fatty acid content in danish food. First International Symposium on trans fatty acids and health. Rungstedgaard, Denmark, September 11-13, Abstract.
Mattson FH, Volpenhein RA. 1964. The digestion and absorption of triglycerides. J. Biol. Chem. 239, 2772-2777. PMid:14216426
Mattson FH, Nolen GA, Webb MR. 1979. The absorbability by rats of various triglycerides of stearic and oleic acid and the effect of dietary calcium and magnesium. J. Nutr. 109, 1682-1687. PMid:490206
Mennen L, de Maat M, Meijer G, Zock P, Grobbee D, Kok F, Kluft C, Schouten E. 1998. Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized trial. Arterioscler. Thromb. Vasc. Biol. 18, 599-603. PMid:9555866
Mensink RP, Katan MB. 1992. Effect of dietary fatty acids on serum lipids and lipoproteins. A Meta-analysis of 27 Trials. Arterioscler. Thromb. 12, 911-919. PMid:1386252
Mensink RP, Zock PL, Kester AD, Katan MB. 2003. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL-cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am. J. Clin. Nutr. 77, 1146-1155. PMid:12716665
Mitropoulos K, Miller G, Martin J, Reeves B, Cooper J. 1994. Dietary fat induces changes in factor VII coagulant activity through effects on plasma free stearic acid concentrations. Atheroscler. Thromb. 14, 214-222. PMid:8305411
Morin O. 2007. Huiles végétales et margarines : évolution de la qualité - Les solutions technologiques à la réduction des acides gras trans. Cah. Nutr. Diét., 42, 5, A paraître.
Mozaffarian D, Katan M, Ascherio A, Stampfer M, Willett W. 2006. Trans fatty acids and cardiovascular disease. New Engl. J. Med. 354, 1601-1613. doi:10.1056/NEJMra054035 PMid:16611951
Mozaffarian D, Aro A, Willett W. 2009. Health effects of trans-fatty acids: experimental and observational evidence. Europ. J. Clin. Nutr. 63, S5-S21. doi:10.1038/sj.ejcn.1602973 PMid:19424218
Mozaffarian D, Clarke R. 2009. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur. J. Clin. Nutr. 63, S22-S33. doi:10.1038/sj.ejcn.1602976 PMid:19424216
Mu H, Hø´ y C. 2004. The digestion of dietary triacylglycerols. Prog. Lipid. Res. 43, 105-133. doi:10.1016/S0163-7827(03)00050-X
Nestel PJ, Pomeroy S, Kay S, Sasahara T, Yamashita T. 1998. Effect of a stearic acid-rich, structured triacylglycerol on plasma lipids concentrations. Am. J. Clin. Nutr. 68, 1196-1201. PMid:9846846
Rhee SK, Adlof RO, Ciszek A, Brenna JT. 1997. Desaturation and interconversion of dietary stearic and palmitic acid in human plasma and lipoproteins. Am. J. Clin. Nutr. 65, 451-458. PMid:9022530
Rodríguez-Meléndez R, Rasmussen HE, Lee JY, Carr TP. 2006. NPC1L1 gene expression is downregulated by stearic acid in CCL-241 cells. Faseb J. 20, 138-145.
Sanders T, de Grassi T, Miller G, Morrissey J. 2000. Influence of fatty acid chain-lenght and cis/trans isomerization on postprandial lipemia and Factor VII in healthy subjects. Atherosclerosis 149, 413-420. doi:10.1016/S0021-9150(99)00335-4
Salmeron J, Hu FB, Manson JE, Stampfer MJ, Colditz GA, Rimm E B, Willett W. 2001. Dietary fat intake and risk of type 2 diabetes in women. Am. J. Clin. Nutr. 73, 1019-1026. PMid:11382654
Saravanan N, Haseeb A, Ehteham NZ, Ghafoorunissa X. 2005. Differential effects of dietary saturated and trans fatty acids on expression of genes associated with insulin sensitivity in rat adipose tissue. Eur. J. Endocrinol. 153, 159-165. doi:10.1530/eje.1.01946 PMid:15998628
Simon J, Fong J, Bernert J. 1996. Serum fatty acids and blood pressure. Hypertension 27, 303-307. PMid:8567056
Snook J-T, Park S, Williams G, Tsai YH, Lee, N. 1999. Effect of synthetic triglycerides of myristic, palmitic, and stearic acid on serum lipoprotein metabolism. Eur. J. Clin. Nutr. 53, 597-605. doi:10.1038/sj.ejcn.1600815 PMid:10477245
Steer P, Millgard J, Sarabi D, Basu S, Vessby B, Kahan T, Edner M, Lind L. 2002. Cardiac and vascular structure and function are related to lipid peroxidation and metabolism. Lipids 37, 231-236. doi:10.1007/s11745-002-0885-3 PMid:11942472
Stender S, Dyerberg J, Astrup A. 2006. High levels of trans fat in popular fast foods. N. Engl. J. Med. 354, 1650-1652. doi:10.1056/NEJMc052959 PMid:16611965
Storm H, Thomsen C, Pedersen E, Rassmussen O, Christiansen C, Hermansen K. 1997. Comparison of a carbohydrate-rich diet and diets rich in stearic or palmitic acid in NIDDM patients. Effects on lipids, glycemic control, and diurnal blood pressure. Diabetes Care 20, 1807-1813. doi:10.2337/diacare.20.12.1807 PMid:9405898
Sundran K, Ismail A, Hayes K, Jeyemalar R, Pathmanathan R. 1997. Trans (elaidic) fatty acids adversely affect the lipoprotein profile relative to specific saturated fatty acids in humans. J. Nutr. 127, 514S-520S.
Sundran K, Karupaih T, Hayes K. 2007. Stearic acid-rich interesterified fat and trans-rich fat raise the LDL/HDL ratio and plasma glucose relative to palm olein in humans. Nutrition & Metabolism 4, 3-15.
Tanasescu M, Cho E, Manson JE, Hu FB. 2004. Dietary fat and colesterol and the risk of cardiovascular disease among women with type 2 diabetes. Am. J. Clin. Nutr. 79, 999-1005. PMid:15159229
Tarragó-Trani T, Phillips K, Lemar L, Holden J. 2006. New existing oils and fats used in products with reduced trans-fatty acid content. J. Am. Diet Assoc. 106, 867-880. doi:10.1016/j.jada.2006.03.010 PMid:16720128
Thijssen MA, Mensink R P. 2005. Small differences in the effects of stearic acid, oleic acid, and linoleic acid on the serum lipoprotein profile of humans. Am. J. Clin. Nutr. 82, 510-516. PMid:16155261
Thijssen MA, Hornstra G, Mensink R. 2005. Stearic, oleic, and linoleic acids have comparable effects on markers of trombotic tendency in healthy human subjects. J. Nutr. 135, 2805-2811. PMid:16317124
Tholstrup T, Marckmann P, Jespersen J, Sandtrom B. 1994. Fat high in stearic acid favorably affects blood lipids and Factor II coagulant activity in comparison with fats high in palmitic acid or high in myristic and lauric acids. Am. J. Clin. Nutr. 59, 371-377. PMid:8310987
Tholstrup T, Marckmann P, Vessby B, Sandstrom B. 1995. Effects of fats high in individual saturated fatty acids on plasma lipoprotein(a) levels in young healthy men. J. Lipid Res. 36, 1447-1452. PMid:7595068
Tholstrup T, Samman S. 2004. Postprandial lipoprotein(a) is affected differently by specific individual dietary fatty acids in healthy young men. J. Nutr. 134, 2550-2555. PMid:15465746
Uauy R, Aro A, Clarke R, Ghafoorunissa X, L’Abbé M, Mozaffarian D, Skeaff CM, Stender S, Tavella A. 2009. WHO Scientific update on trans fatty acids: summary and conclusions. Eur. J. Clin. Nutr. 63, S68-S75. doi:10.1038/ejcn.2009.15
U.S. Food and Drug Administration and Center for Food Safety and Applied Nutrition 2003. Food Labelling: Trans fatty acids in nutrition labeling, nutrient content claims, and health claims. Federal Register 68, 41434-41506.
Valenzuela A, Morgado N. 1999. Trans fatty acid isomers in human health and in the food industry. Biol. Res. 32, 273-287. doi:10.4067/S0716-97601999000400007 PMid:10983247
Valenzuela A. 2008. Trans fatty acid consumption in Latin America. In “Healthy oils and the elimination of industrially produced trans fatty acids in the Americas” Pan American Health Organization (PAHO) Document, Washington DC, pp 15-27.
Valenzuela A. 2008a. Ácidos grasos con isomería trans II. Situación de consumo en Latinoamérica y alternativas para su sustitución. Rev. Chil. Nutr. 35, 172-180.
Yu S, Derr J, Etherton T, Kris-Etherton P. 1995. Plasma cholesterol-predictive equations demonstrate that stearic acid is neutral and monounsaturated fatty acids are hypocholesterolemics. Am. J. Clin. Nutr. 61, 1129-1139. PMid:7733039
Zock P, Blijlevens R, de Vries J, Katan M. 1993. Effects of stearic acid and trans fatty acids versus linoleic acid on blood pressure in normotensive women and men. Eur. J. Clin. Nutr. 47, 437-444. PMid:8365385
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