Synthesis, antibacterial and surface activity of 1,2,4-triazole derivatives

R. El-Sayed

doi:10.3989/gya.2006.v57.i2.35

Autores/as

R. El-Sayed Chemistry Department, Faculty of Science, Benha Unviversity

DOI:

https://doi.org/10.3989/gya.2006.v57.i2.35

Palabras clave:

1, 2, 4-Triazol derivatives, Synthesis, Antibacterial properties, Surface activity properties

Resumen

Es interesante el uso del 1-(4-amino-5-mercapto-4H- [1,2,4]triazol-3-il)heptadecano-1-sulfonato sódico (2) como un nuevo precursor en la síntesis de compuestos heterocíclicos biológicamente importantes. La reacción de 2 con disulfuro de carbono en piridina y cloruros de acilo rindió derivados 1,2,4-triazólicos. Condensación de 2 con aldehídos apropiados produjo 5a-c que ciclaron por tratamiento con ácido tioglicólico para dar lugar a 6a-c. Reacciones de 2 con anhídrido ftálico y cloruro de 4-metilbenzenosulfonilo produjeron 7 y 8. Además, la reacción de 2 con cloroacetaldehído, bromuro de fenacilo, urea, cloruro de tiacetilo produjo 9, 10, 11, y 12. Por otra parte, el reflujo de 2 con isocianato de fenilo dio 13 y 14. Todos los productos tuvieron actividad antimicrobiana y propiedades tensoactivas.

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Citas

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