Cholesterol metabolism, its regulation at the hepatic and intestinal level


  • M. T. Molina Facultad de Farmacia. Universidad de Sevilla
  • C. M. Vázquez Facultad de Farmacia. Universidad de Sevilla
  • V. Ruiz Gutiérrez Instituto de la Grasa y sus Derivados (CSIC)



Cholesterol (metabolism), Enzymatic activity, Information (paper), Lipid composition, Membrane


Although all the cells in the body are able to form cholesterol, most part of this synthesis, leading to which is called endogenous cholesterol, occurs in the liver. Hepatocytes can also obtain cholesterol from the plasma lipoproteins. At the same time, cholesterol is either secreted from the liver in new plasma lipoproteins or transformed in bile acids. The extrahepatic cholesterol is mainly produced in the intestinal mucosa. In the site, it takes place the absorption of cholesterol from the diet (exogenous cholesterol), along with the biosynthesis of new cholesterol and the esterification of the molecule to be stored in the cell or secreted as plasma lipoproteins. At the cellular level, the importance of cholesterol comes from the fact that many of the membranous structures of all cells are partially composed of these substance. In this article some of these aspects of the cholesterol metabolism are reviewed. We also describe the influence of lipid composition of microsomal membranes on the activity of cholesterol metabolism regulating enzymes.


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How to Cite

Molina MT, Vázquez CM, Ruiz Gutiérrez V. Cholesterol metabolism, its regulation at the hepatic and intestinal level. Grasas aceites [Internet]. 1991Aug.30 [cited 2024May29];42(4):298-30. Available from:




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